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Chang. PLCPRF5. HepG2. HuH-7. Hep3B. A. ICL-agents. 4.5. 18.6. 8.0. 3.4. 7.7. proliferation index. MMC [nM]. cisplatin [ μ M]. melphalan [ μ M]. non-ICL-agents. proliferation index. etoposide [ μ M]. 5-FU [ μ M]. doxorubicin [ μ M]. B. C. HuH-7. HuH-7. Hep3B.

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**Chang**PLCPRF5 HepG2 HuH-7 Hep3B A ICL-agents 4.5 18.6 8.0 3.4 7.7 proliferation index MMC [nM] cisplatin [μM] melphalan [μM] non-ICL-agents proliferation index etoposide [μM] 5-FU [μM] doxorubicin [μM] B C HuH-7 HuH-7 Hep3B Cells in G2/M cell count in % cell count in % Chang MMC [nM] MMC [nM] cell count PLCPRF5 HepG2 Chang Cells in G2/M cell count in % cell count in % Hep3B MMC [nM] MMC [nM] PLCPRF5 HepG2 Cells in G2/M cell count in % S G2/M G1 DNA content - MMC (25 nM) + MMC [nM]

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