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Virsuses: Human Immunodeficiency Syndrome & Acquired Immunodeficiency Syndrome

Virsuses: Human Immunodeficiency Syndrome & Acquired Immunodeficiency Syndrome. Outline we may need to save some topic in lecture. Origins of HIV based on scientific evidence HIV viral particle Mechanism of infection Transmission Treatment AIDS Prevention. Red capped mangabey monkey.

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Virsuses: Human Immunodeficiency Syndrome & Acquired Immunodeficiency Syndrome

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  1. Virsuses:Human Immunodeficiency Syndrome& Acquired Immunodeficiency Syndrome

  2. Outlinewe may need to save some topic in lecture • Origins of HIV based on scientific evidence • HIV viral particle • Mechanism of infection • Transmission • Treatment • AIDS • Prevention

  3. Red capped mangabey monkey Greater spot nose monkey SIV cpz almost identical to HIV 1 Humans

  4. Pan troglodytes troglodytes Simian Virus (SIV cpz) almost identical to HIV 1

  5. Sooty mangabey monkey Simian Virus corresponds to HIV2

  6. HIV: Structure and mechanism of replication

  7. HIV

  8. HIV-1 PARTICLE

  9. The key HIV genes

  10. Mechanism of Infection Infects Th cell VIRAL RNA Integrates into host DNA “activated” PROVIRAL DNA LYTIC STAGE storage LYSOGENIC STAGE

  11. RETROVIRAL REPLICATION

  12. HIV animations http://www.hivinfosource.org/hivis/hivbasics/animations/index.html http://search.live.com/video/results.aspx?q=HIV+animation&docid=1601834254601#docid=1601834254601 http://search.live.com/video/results.aspx?q=HIV+animation&docid=1601834254601#docid=1669495456158

  13. T lymphocyte in green and HIV in red

  14. HIV and helper T cells HIV-1 HOST CELLS:helper T lymphocyte, macrophages

  15. LYTIC STAGE

  16. Transmission of HIV

  17. Transmission of HIV • Biological fluids • Blood • Sexual transmission (Semen) • Breast milk • Transplant tissues

  18. Non-transmitting sources of HIV • Tears • Saliva • Mosquito or insects • Swimming pool • Food handling

  19. Highly Active Antiretroviral Therapy (HAART)Cocktail Therapy

  20. Examples of anti-retroviral drugs • Cocktail Drug Mixtures • Protease inhibitors • Non-nucleoside RT Inhibitors (NNRTIs) • Nuleoside/nucleotide RT inhibitors (NRTIs) • * Fusion Inhibitors *Fuzeon • Integrase Inhibitors

  21. Fusion Inhibitors block • Co-receptors on host cell • Gp120/gp 41 on viral particle or

  22. Co-Receptors Binds naturally occurring chemokines CCR5 or CXCR4 (fusin)

  23. Prevention • Condoms • Clean needles • Treatment of pregnant mother with anti-viral drugs • Blood screening • Abstinence

  24. Acquired Immunodeficiency Disease

  25. Symptoms of AIDS • Decrease T cell count • Rapid weight loss • Recurring fever and dry cough • Profound fatigue • Swollen lymph glands

  26. Symptoms of AIDS • Persistent diarrhea • Unusual blemishes on the tongue, mouth, or throat • pneumonia • memory loss, depression

  27. Acquired Immunodeficiency SyndromeOpportunistic Diseases and cancer • pneumonia • Kaposi’s Sarcoma Kaposi’s Sarcoma

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