1 / 6

Correlate P hosphorylation Sites to K inases by Conditional Random Fields --- CS 104 Project

Correlate P hosphorylation Sites to K inases by Conditional Random Fields --- CS 104 Project. Lu He, Tuobin W ang . Background and Problem. Problem:

keiji
Télécharger la présentation

Correlate P hosphorylation Sites to K inases by Conditional Random Fields --- CS 104 Project

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Correlate Phosphorylation Sites toKinasesby Conditional Random Fields --- CS 104 Project Lu He, TuobinWang

  2. Background and Problem Problem: Given groups of kinases and groups of phosphorylatedproteins, our problem focuses on correlating phosphorylated proteins with corresponding kinases.

  3. Challenges and Methods Challenges: Dependency of amino acids around Phosphorylation site {Y, S, T} !! Method:Conditional Random Fields vs.SVM, HMM

  4. Data Set and Evaluation Phospho.ELM website: In vivo protein-phosphorylationsites that are linked to at least one kinase Evaluation: • 5-fold cross validation • TP, TN, FP, FN

  5. Timeline • Feb 8: Project proposal; • Feb 9 - Feb 14: Collect data, learning relevant knowledge. • Feb 15 - Feb 22: Coding and solving encountered problems. • Feb 23 - Mar 2: Finish coding and experiments; • Mar 3 - Mar 7: Analyzing and discussing the results of experiments. Finishing the final write-up and poster.

  6. Thanks !

More Related