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Drug Forms. Development of Drug.

Drug Forms. Development of Drug. Original drug (Brand name drug) – a drug on the market that contains medication not known before. It is protected several years by patent, since a company spent money on research, marketing and promotion.

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Drug Forms. Development of Drug.

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  1. Drug Forms. Development of Drug.

  2. Original drug (Brand name drug)– a drug on the market that contains medication not known before. It is protected several years by patent, since a company spent money on research, marketing and promotion. Generic drug – is a drug without patent protection. Needs to be bioequivalent to the brand name drug with respect to pharmacokinetic and pharmacodynamic properties.

  3. Ways of administration Way of administration is the way through which drug reaches organism. Way of adinistration depends on drug form, physical and chemical properties of the drug and psysical and mental state of the patient. Ways of administration are divided to local (topic) and systemic. Systemic administration can be enteral or parenteral. local Administration enteral systemic parenteral

  4. Druf forms can be divided according to consistency to liquid, solid, semisolid and gaseous. Drug forms can also be set for internal or external use.

  5. Solid drug forms • tablets • coated tablets • tablet or capsule with retarded drug release • capsules • powders • granulationes • species

  6. Semisolid drug forms • ointment • cream • paste • suppository • patch

  7. Liquid drug forms • enteral • peroral administration • solution • syrup • drops (eye drops can´t be opened more than one month) • rectal administration • clysma • parenteral • injections • infusion • transfusions • local • solutions • emulsions • suspensions • foams

  8. Gaseous drug forms • Aerodispersions

  9. Drug development • synthesis of novel chemical compounds • preclinical testing (cell cultures, isolated cells, isolated organs  animals) • clinical trials phase I (healthy people) • clinical trials phase II (selected patients) • clinical trials phase III (large group of patients, the drug is compared to conventional treatments, e.g. “double-blind“ study) • registration of the drug (a national regulatory body) • clinical trials phase IV (surveillance after licence)

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