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Immunotherapy for Head and Neck Cancer?

Immunotherapy for Head and Neck Cancer?. Thomas K. Hoffmann. Dept. of Otorhinolaryngology. ADCC (NK-cell). Immune Cell Infiltration. Anti-EGFR-Antibody. • Targeted Therapy • Signaling ↓ • Immunotherapy?. HNSCC. + Immune Cells. CD3/ 14 /16. Immune Cell Infiltration. Native.

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Immunotherapy for Head and Neck Cancer?

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  1. Immunotherapy for Head and Neck Cancer? Thomas K. Hoffmann Dept. of Otorhinolaryngology

  2. ADCC (NK-cell) Immune Cell Infiltration Anti-EGFR-Antibody • Targeted Therapy • Signaling ↓ • Immunotherapy? HNSCC

  3. + Immune Cells CD3/14/16 Immune Cell Infiltration Native + Immune Cells + anti-EGFR Ab Array+Functional Assays: MCP-1

  4. Active Vaccine Immunotherapy for Head&Neck Cancer Antibody Passive Immunotherapy

  5. Vaccine • Variolae Vaccinae Edward Jenner (1749-1823) • Active Immunisisation • Tumor antigen as vaccine • Induction of T-cell response

  6. Peptides Protein DC Antigen presenting cell p53 Lysate/Apo HPV16 EGFR RNA/DNA Induction of T-cell response Tumor cell T-cells Antigen

  7. Clinical Pilot Studies • DC+APO – closed – technically difficult • DC+p53 Peptides – open • DC+DNA – open • HNSCC+Newcastle Disease Virus – closed

  8. Immunotherapy for Head and Neck Cancer? • Anti-EGFR-Ab – passive IT • Vaccination – active IT • Combination – fighting MRD • Induction of tumor-specific memory

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