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IMMUNOTHERAPY FOR CANCER

IMMUNOTHERAPY FOR CANCER. Spontaneous. UV and ionizing radiation. Chemical carcinogens. Tumour induction. Genetic abnormalities (XP). Virus-induced (HepC, EBV, HPV). Immunosuppression. Causative agents. INTRODUCTION. Abnormal Demerits of older methods don’t offer complete cure

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IMMUNOTHERAPY FOR CANCER

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  1. IMMUNOTHERAPY FOR CANCER

  2. Spontaneous UV and ionizing radiation Chemical carcinogens Tumour induction Genetic abnormalities (XP) Virus-induced (HepC, EBV, HPV) Immunosuppression Causative agents

  3. INTRODUCTION • Abnormal Demerits of older methods • don’t offer complete cure • poor selectivity cancer vs normal • poor efficacy against slow growing cells

  4. Principles • Total cell kill • Minimize toxicity to normal cells

  5. For what it is designed • Elicit or amplify d imm response, that’s by ; activation imm therapy suppression imm therapy

  6. Activation imm therapy • Administration of cytokines • Adverse effect lead to extraction of lymphocytes from the blood • Expand invitro against tumour antigen

  7. immunomodulators • Active agents collectively called as…. • interleukins • cytokines • interferone • glucans

  8. Proceed in two ways • Immunization of the patient • Admin of therapeutic Ab as drugs(recruits)

  9. Leukins activate d lymphocytes • Il 2 melanoma,renal caner • Side effect : malaise,flu like • Inteferons slows down d tumourgth. This is by stimulating t cells and macrophages. These 2 together. • Alpha approved by FDA

  10. Cell based • Monoclonal • Radioimmunotherapy • Topical • Natural products

  11. Name the imm cells • Isolation of allogenic or autologos • Enriching outside • Now d injected imm cells are highly cytotoxic • So helping to fight

  12. AIET • If d use of autlogos then it is called • Cultured proceussed • Until resistance to cancer is stengthened • Put back • Immidiately after recognizing NK cells attack the cancer cells • New method

  13. Carefully engineered…… • Specific defects in cancer cells

  14. How do mAB drugs work • 3 ways • Make cancer cell more visible • Block growth signals • Deliver radiations to cancer cells

  15. Roleof mAB in b.c • HER 2 • Trastuzumab(herceptin) • Her pstv over expression of genes • Immunohistochemical analysis • Firsrt dose 90 mint

  16. Able to kill metastatic cancer cell anywhere in the body • With the help of Ab and substance producing radiation • Antibody attach to an isotope • Travel around the body until they encounter a cancer cell • Difficulties…………

  17. Example,murineab against cellular antigen • Mainly lybmphomas • Bcz highly sensitive y murineab • Limit radiation exposure • Rapid clearance

  18. Topical immunotherapy • Immune enhancement cream-imiquimod • Which is an interferone producer • Destroy warts • Actininkeratoses • Superficial spreading melanoma

  19. Agaricusstimulat immune system • Potent stimulator of natural killer cells • Proteoglucans and beta glucans

  20. References www.cancer.org www.immunotreatment.org www.cancersupportivecare.org www.cancercentre .com www.springer.com

  21. Thank you

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