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BMS

B. A. SK-N-SH cells, 24 h after irradiation. SK-N-SH cells, 48 h. 72 h after irradiation. 0 Gy. 5 Gy. Apo G1 G2/M. Apo G1 G2/M. Apo G1 G2/M. Apo G1 G2/M. 0 Gy. Cont. 2 76 9%. 2 71 17%.

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BMS

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  1. B A SK-N-SH cells, 24 h after irradiation SK-N-SH cells, 48 h 72 h after irradiation 0 Gy 5 Gy Apo G1 G2/M Apo G1 G2/M Apo G1 G2/M Apo G1 G2/M 0 Gy Cont 2 76 9% 2 71 17% 4 70 23% 3 61 20% 5 Gy 62 34 2% 38 38 10% 81 18 1% 17 54 19% BMS 59 34 3% 10 Gy 40 36 13% 55 51 3% 26 68 5% Stat3 -inh6 Cell number DNA content 76 23% 28 70% LY Cell number Suppl. Fig. 3. (A, B). Radiation response of SK-N-SH neuroblastoma cells in the absence and in the presence of inhibitors of the cell survival pathway BMS345541 (IKK-NF-kB), Stat3-inhibitor-6 and LY294002 (PI3K-AKT). Cell cycle-apoptosis analysis was performed using PI staining of DNA and FACS analysis. DNA content

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