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Ctnnb1 deletion

A. I. III. a. b. c. d. b. II. II’. Ctnnb1 deletion. d. a. EGFR-L858R-T790M. c. B.

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Ctnnb1 deletion

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  1. A I III a b c d b II II’ Ctnnb1 deletion d a EGFR-L858R-T790M c B Supplementary Figure S7. Incomplete deletion of β-catenin gene leads to tumor formation in EGFRTL/CCSP-rtTA/Cre/Ctnnb1F/Fmice. (A) H&E staining of lungs isolated from I: CCSP-rtTA/Ctnnb1F/+; II and II’: EGFRTL/CCSP-rtTA/Cre/Ctnnb1F/F; III: EGFRTL/CCSP-rtTA/Cre/Ctnnb1F/+. Scale bar = 10 mm. (B) Representative PCR analysis of Ctnnb1deletion. Four lung areas (a-d) in the panel II’ in (A) were procured by laser capture microdissection. Then DNA was isolated and analyzed.

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