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Group 4: Integrated Fluorescent Probe and RF Ablator

Group 4: Integrated Fluorescent Probe and RF Ablator. Rachel Riti Alex Walsh. What is Radiofrequency Ablation?. Minimally invasive Treats small tumors Radiofrequency Waves 1. 2. Fluorescence. What is Fluorescence? 4 Yield vs. Temperature 5-7. 8. Fiber Optics. Fiber Optic Probe

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Group 4: Integrated Fluorescent Probe and RF Ablator

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  1. Group 4:Integrated Fluorescent Probe and RF Ablator Rachel Riti Alex Walsh

  2. What is Radiofrequency Ablation? • Minimally invasive • Treats small tumors • Radiofrequency Waves1 2

  3. Fluorescence • What is Fluorescence?4 • Yield vs. Temperature5-7 8

  4. Fiber Optics • Fiber Optic Probe • Total Internal Reflection • Flexible • Measures Fluorescence 10 9

  5. Current Technology • Thermocouples 11

  6. Objectives • Design a probe capable of both fluorescence measurements and RFA • Build the designed probe • Test the probe

  7. Integration • RF Ablator • Fiber Optics 3

  8. References 1"Radiofrequency Ablation." S. Mark Taper Foundation Imaging Center. Cedars Sinai Health System, 2000. <http://www.csmc.edu/10778.html>. 2"Ablation of Liver Tumors." The University of Texas M. D. Anderson Cancer Center. 1999. <http://www.wentek.com/jean/ablation.htm>. 3"Laparoscopic radiofrequency ablation therapy (LRFA) for the treatment of hepatocellular carcinoma." Third Department of Internal Medicine. Niigata University School of Medicine, 9 May 2002. <http://www.med.niigata-u.ac.jp/in3/old/laparo/LMCTandLRFA.html>. 4Lakowicz, Joseph R. Principles of fluorescence spectroscopy. 3rd ed. Baltimore: Springer Science+Business Media, LLC, 2006. 5Menter, Julian M. “Temperature dependence of collagen fluorescence.” Photochemical and Phtotbiological Sciences. 2006 5, 403-410. 6A. Oliver, G. Baker, R. Fugate, F. Tablin, and J. Crowe, "Effects of Temperature on Calcium-Sensitive Fluorescent Probes," Biophysical Journal, vol. 78, pp 2116-2126, 2000. 7E. Bowen, and J. Sahu. "The Effect of Temperature on Fluorescence of Solutions," Journal of Physical Chemisty, vol. 63, pp 4-7, 1959. 8"Fluorescence." Be Seen On a Bike. <http://www.beseenonabike.com/bsoab/beseenonabike_info_fluorescence.htm>. 9"How Fiber Optics Work." Howstuffworks "Electronics.” 09 Nov. 2009. <http://electronics.howstuffworks.com/fiber-optic.htm>. 10"40 Principles of Invention #2: Taking Out [TRIZ]." Paprika Lab. 25 June 2008. <http://paprikalab.com/blog/?p=165>. 11 RITA Medical Systems, “RITA Starburst SDE Electrosurgical Device.” Instructions for Use.

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