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Longitudinal Nationwide Antimicrobial Susceptibility Surveillance in Ocular Isolates: Results from Ocular TRUST 2

Longitudinal Nationwide Antimicrobial Susceptibility Surveillance in Ocular Isolates: Results from Ocular TRUST 2. Penny A. Asbell, MD 1 Daniel F. Sahm, MD 2 1 Mount Sinai School of Medicine, New York, NY; 2 Eurofins Medinet, Inc, Anti-Infective Services, Herndon, VA.

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Longitudinal Nationwide Antimicrobial Susceptibility Surveillance in Ocular Isolates: Results from Ocular TRUST 2

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  1. Longitudinal Nationwide Antimicrobial Susceptibility Surveillance in Ocular Isolates:Results from Ocular TRUST 2 Penny A. Asbell, MD1 Daniel F. Sahm, MD2 1Mount Sinai School of Medicine, New York, NY; 2Eurofins Medinet, Inc, Anti-Infective Services, Herndon, VA Financial Disclosure: Dr. Asbell has served as a consultant to Inspire Pharmaceuticals and has received lecture fees from Alcon Laboratories, Allergan Pharmaceuticals, Santen Pharmaceutical, Inspire Pharmaceuticals, and Vistakon Pharmaceuticals. Dr. Sahm is a full-time employee of Eurofins Medinet, Inc., Anti-Infective Services and has received lecture fees from Vistakon Pharmaceuticals.

  2. Ocular TRUST: Nationwide Antimicrobial Susceptibility Surveillance Program • Ocular isolates only • Initiated in 2005 • Largest surveillance program with centralized in vitro susceptibility testing • Annual surveys providing longitudinal data

  3. Ocular TRUST 2 (2006-2007)

  4. State with participating institution Participating Eye Centers (10) Ocular TRUST: Participating Sites

  5. 100 80 60 40 20 AZI AZI CIP CIP TRI TRI PEN PEN TOB TOB LEV LEV GAT GAT MOX MOX PLYX PLYX Ocular TRUST 2: S. aureus Susceptibility MRSA (N=84) MSSA (N=71) % Susceptible 18

  6. 100 80 60 40 20 AZI AZI CIP CIP TRI TRI PEN PEN TOB TOB LEV LEV GAT GAT MOX MOX PLYX PLYX Ocular TRUST 2: Coagulase-Negative Staphylococci Susceptibility Methicillin-resistant (N=52) Methicillin-susceptible (N=40) 44 % Susceptible

  7. 100 80 60 40 20 AZI AZI CIP CIP TRI TRI PEN PEN TOB TOB LEV LEV GAT GAT MOX MOX PLYX PLYX Ocular TRUST 2: S. pneumoniae and H. influenzae Susceptibility H. influenzae (N=144) S. pneumoniae (N=198) 100 % Susceptible

  8. Ocular TRUST 2: Overview • Methicillin resistance in staphylococci marker for multi-drug resistance • Fluoroquinolones most consistently active agents across ocular pathogens • Fluoroquinolone susceptibility profile • Gatifloxacin = Levofloxacin = Moxifloxacin • Modest diminution in S. pneumoniaesusceptibility to ciprofloxacin • Polymixin B and penicillin most limited activity

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