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Glucose

Reabsorption: > large amounts are filtered >for many substances, large amounts are reabsorbed, so little is excreted. Glucose. Urea. Table 27-1. Brush border. Reabsorption across tubular epithelial cells. Figure 27-1.

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Glucose

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  1. Reabsorption: > large amounts are filtered >for many substances, large amounts are reabsorbed, so little is excreted Glucose Urea Table 27-1

  2. Brush border Reabsorption across tubular epithelial cells Figure 27-1

  3. Pressures favoring reabsorption by bulk flow into peritubular capillaries Figure 27-15

  4. Sodium reabsorption in the proximal tubule Figure 27-2

  5. Secondary active transport Version from the Silverthorn text Figure 27-3

  6. Figure 14.23Page 534 Passive reabsoprtion of some substances Glomerulus Peritubular capillary Bowman’s capsule 125 ml of filtrate Beginning of proximal tubule Na+ (active) H2O (osmosis) Na+ (active) H2O (osmosis) 44 ml of filtrate End of proximal tubule Passive diffusion of urea down its concentration gradient = Urea molecules

  7. Importance of transport maxima Substance Transport Maximum Glucose 375 mg/min Phosphate 0.10 mM/min Sulfate 0.06 mM/min Amino acids 1.5 mM/min Urate 15 mg/min Lactate 75 mg/min Plasma protein 30 mg/min Transport Maximums for Substances That Are Actively Secreted. Substances that are actively secreted Substance Transport Maximum Creatinine 16 mg/min Para-aminohippuric acid 80 mg/min Figure 27-4

  8. Silverthorn Figure 19-15 - Overview

  9. Different segments are specialized for different things: Proximal Tubule: REABSORBTION, secretion Figure 27-6

  10. Figure 27-7

  11. We’ll save loop of Henle for next time Figure 27-8

  12. Distal tubule and collecting duct: regulated reabsorption and secretion Figure 27-11

  13. (a wonderful figure; pay attention to: • Glucose and amino acids • Na+, K+, Cl- • Urea • Inulin and creatinine • PAH Figure 27-14

  14. Key hormones involved in the regulation of reabsorption Table 27-3 (we’ll focus on aldosterone and antidiuretic hormone during the next two classes)

  15. For a substance that is freely filtered, but not reabsorbed or secreted: Silverthorn Figure 19-16

  16. Figure 27-19

  17. Silverthorn Table 19-2

  18. Clearance: or Silverthorn Figure 19-17 - Overview

  19. Table 27-4

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