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C-H Activation Borylation The Holy Grail of Catalysis

2. C-H activation: Process where a strong C-H bond undergoes substitution to produce a weaker C-M bond.Functionalisation: Metal-C bond is replaced by any bond except C-H.The challenge: Finding ways to selectively form the C-M intermediate under synthetically useful, mild conditions that enable functionalisation and catalyst renewal..

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C-H Activation Borylation The Holy Grail of Catalysis

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    1. 1

    2. 2

    3. 3

    4. 4 18 Electron Rule

    5. 5 Direct Borylation of Alkanes: Initial Work

    6. 6 Direct Borylation of Alkanes: Initial Work Proposed Mechanism

    7. 7

    8. 8

    9. 9 Direct Borylation of Alkanes: Thermal

    10. 10

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    14. 14 Proposed high-valent Rh(V) and Ir(V) boryl complexes as intermediates in these reactions

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    25. 25

    26. 26 Direct Arene Borylation : Suzuki Precursors

    27. 27 Direct Arene Borylation : One Pot Oxidation

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