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Supporting Information

Supporting Information

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Supporting Information

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  1. Supporting Information Figure S1. Evidence of renal injury in 16-week-old db/db mice. albumin excretion rate (AER: a), glomerular volume (VG: b), fractional mesangial area (FMA: c), and glomerular expression of fibronectin and VEGF, and pentosidine deposition (d) were measured as described in Methods. Data are presented as mean ± SE of 5 mice/group. C: db/m treated with 0.9% NaCl for 8 weeks from age 8 weeks, D: db/db treated with 0.9% NaCl for 8 weeks from age 8 weeks, *P<0.05 compared to control db/m mice.

  2. Supporting Information Figure S2. Effect of ALA on renal mRNA expression of NADPH oxidase subunit p47 phox (a), p67 phox (b), Nox2 (c) and Nox4 (d). Realtime quantitative PCR was done for mRNA expression using pooled RNA from each group. C: db/m treated with 0.9% NaCl for 12 weeks from age 8 weeks, CALA: db/m treated with ALA for 12 weeks from age 8 weeks, D: db/db treated with 0.9% NaCl for 12 weeks from age 8 weeks, DALAE: db/db treated with ALA for 12 weeks from age 8 weeks, DALAL: db/db treated with ALA for 4 weeks from age 16 weeks. ALA 2 mg/kg/day was i.p. administered.

  3. Supporting Information Table S1. Primers used in this study.

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