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Ondansetron (Zofran) Protocol for Prehospital Antiemetic Use in EMS

The Southeastern Massachusetts EMS Council has established a protocol for the use of Ondansetron (Zofran) as an antiemetic by EMT-CC and EMT-P. This medication is indicated for the prevention and treatment of nausea and vomiting, particularly in patients with known hypersensitivity to other antiemetic medications such as Anzemet, Kytril, and Aloxi. Caution is advised for patients taking certain medications like phenytoin or carbamazepine. Side effects may include blurred vision, heart rate changes, dizziness, and gastrointestinal disturbances. Dosage should be up to 4mg IV as per medical control orders.

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Ondansetron (Zofran) Protocol for Prehospital Antiemetic Use in EMS

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  1. Ondansetron - 2008 Southeastern Massachusetts EMS Council

  2. Antiemesis • Protocol applies to EMT-CC and EMT-P • Indications: • For the prevention and treatment of nausea and vomiting • Contraindications: • Know hypersensitivity to medication

  3. Antiemesis • Protocol uses Ondansetron (Zofran) as the Antiemetic • Agencies may use either the generic or brand name version of this medication

  4. Ondansetron (Zofran) • Indications: • Nausea and vomiting • Contraindications: • Known hypersensitivity to this, or other, antiemetic medications (Anzemet, Kytril, Aloxi)

  5. Ondansetron (Zofran) • Side Effects: • blurred vision or temporary blindness; • fever; • slow heart rate, trouble breathing; • anxiety, agitation, shivering; • feeling light-headed, fainting; or • urinating less than usual or not at all

  6. Ondansetron (Zofran) • Side Effects (continued): • diarrhea or constipation; • weakness or tired feeling; • headache; • dizziness or drowsiness;

  7. Ondansetron (Zofran) • Use Zofran with caution in patients taking the following medications: • phenytoin (Dilantin), phenobarbital (Luminal); • carbamazepine (Carbatrol, Tegretol); • tramadol (Ultram); or • rifampin (Rifadin, Rimactane, Rifater)

  8. Steps: Routine Medical/Trauma Care Ondansetron (Zofran) up to 4mg IV per Medical Control Order Antiemesis

  9. Fentanyl Is Used in What Protocols? • 3.14 Adult Pain And Nausea Management • Medical Control Option • 5.13 Pediatric Pain And Nausea Management • Medical Control Option

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