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The Institute for Medical Research Israel-Canada

The Institute for Medical Research Israel-Canada. The Hebrew University of Jerusalem Faculty of Medicine. David Lichtstein Chairman of IMRIC. John Swidler July 28 th 2011. The Hebrew University of Jerusalem Faculty of Medicine. 1. 2. 3. 4. 5. 1. Hadassah Hospital.

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The Institute for Medical Research Israel-Canada

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  1. The Institute for Medical Research Israel-Canada The Hebrew University of Jerusalem Faculty of Medicine David LichtsteinChairman of IMRIC John Swidler July 28th 2011

  2. The Hebrew University of Jerusalem Faculty of Medicine 1 2 3 4 5 1. Hadassah Hospital 2. School of Medicine (IMRIC) 2 2 3. School of Pharmacy 4. School of Dentistry 5. Botnar Building

  3. The Structure The Institute for Medical Research Israel-Canada

  4. The Institute for Medical Research Israel-Canada Building Thanks to the support of the Canadian Friends of the Hebrew University Construction Renovations

  5. Departments: 5 Research groups: 105 Ms.C. students: 280 Ph.D. students: 400 Undergraduate students: 2500 IMRIC in numbers

  6. IMRIC - Three Layer Organization Departments • Developmental Biology and Cancer Research • Microbiology and Molecular Genetics • Immunology and Cancer Research • Medical Neurobiology • Biochemistry and Molecular Biology • Physiology • Anatomy • Microbiology • Human Genetics • Biochemistry Metabolism and Endocrinology • Neurobiology • Cell Biology and Cancer Research Teaching Divisions Research Centers and Hubs

  7. Four Research Centers The Lautenberg Center for General and Tumor Immunology The Kuvin Center for the Study of Infectious and Tropical Diseases The Hubert H. Humphrey Center for Experimental Medicine and Cancer research The Rogoff Center for Research in Physiology

  8. Ten Research Hubs Microbes and Infectious Diseases The Grafstein Cancer Network Cancer Epigenetics Virus-Host Interactions and Viral Pathogenesis Inflammatory Bowel Disease Cardiovascular Diseases Mitochondrial Function and Diseases Neurodegenerative Diseases Sensori-motor Neuronal Circuits in Health and Disease Signaling Mechanisms in Neurons in Health and Disease

  9. The 2010 EMET Prize The EMET Prize is given for excellence in academic and professional achievements that have far reaching influence and significant contribution to society Prof. Baruch Minke … his outstanding researchers in the field of Sensory Neurobiology have made findings that enable a deeper understanding of the cellular and molecular bases of different sensations, especially that of pain..

  10. Canada Gairdner International Award 2011 The Gairdner Foundation recognizes leading medical researchers from any country in the world for their scientific achievements Prof. Howard Cedar Prof. Aharon Razin For their fundamental contributions to the role of DNA methylationin the control of gene expression

  11. Sir Zelman Cowan Universities Fund Prize, Australia, 2011 The Sir Zelman Cowen Universities Fund Prize for Medical Research recognizes discovery in medical research by researchers under 45 years of age, emphasizing contributions to the understanding or treatment of disease Prof. Sigal Ben-Yehuda Dr. Eli Pikarsky

  12. The Krill Prize of the Wolf Foundation for Excellence in Scientific Research, 2011 Krill Prizes are awarded annually, in Exact Sciences, Life Sciences, Medicine, and Agriculture to excelling faculty members at the Universities in Israel. Dr. Amir Amedi Sight restoration in blind and visually impaired individuals using artificial vision

  13. Fund from the Bill & Melinda Gates Foundation on the Biology and Control of Sand Fly Vector of Leishmaniasis Leishmaniasis is a group of diseases that affect vast population in large areas of the world. The Foundation will support comprehensive studies to elucidate the ecology of VL in Ethiopia and determine the drivers of transmission. Prof. Alon Warburg Dept. Microbiology and Molecular Genetics Sand fly female sucking blood Child with visceral leishmaniasis -Sudan

  14. Israel Centers Of Research Excellence (ICORE-2011) Systems-Level Analysis of the Molecular basis for Human Diseases: From Genomics to Personalized Therapy Hebrew University Tel Aviv University Bar-Ilan University Chaim Sheba Medical Center Hadassah Medical Center, Ein Kerem Prof. Ben-Neriah Yinon, Prof. Dor Yuval, Dr. Hellman Assaf Prof. Mandelboim Ofer Prof. Margalit Hanah, Prof. Howard Cedar

  15. Outstanding Grants for Young Scientists: ERC Grants Dr. Eli Pikarsky Dr. Itamar Simon Dr. Ehud Cohen Dr. Einav Gross

  16. Give me two weeks…… More than 150 Scientific Projects All Oriented To Gain a Wider Perspective of the Etiology, Prevention & Treatment of Human Diseases

  17. Computational physiology of the basal ganglia and their disorders • Identified the subthalamic nucleus as an optimal target for amelioration of Parkinson’s disease. Leads a research and development program of closed-loop DBS therapy. Prof. Hagai Bergman MD, PhD Dept. of Medical Neurobiology Physiological recording in Parkinsonian animal revealing transition from normal to pathological activity Simplified scheme of closed-loop DBS setup

  18. Mechanisms of pancreatic beta cells regeneration Normalization of blood glucose Normalization of islet architecture Blood glucose (mg/dL) Insulin Glucagon Nuclei Wild type Transgenic- ablation Transgenic- recovery +doxycycline Our research is focused on the molecular mechanisms of pancreatic beta cell proliferation and regeneration. Our studies may help to develop novel strategies for regenerative medicine in diabetes. Dr Yuval Dor Dept. of Developmental Biology B A We have developed a transgenic mouse system for conditional ablation of pancreatic beta cells, based on doxycycline-induced expression of Diphtheria toxin in beta cells. Treated mice lose 80% of their beta cells and become diabetic (A). Surprisingly, mice recover from the disease spontaneously (B) and regenerate beta cells (A). We are currently studying the mechanisms underlying this response. Collaboration with Prof. Shapiro, - University of Alberta, Edmonton

  19. Collaborations with Canadian Institutions Epigenetics – McGill University, Montreal- IMRIC Cedar Szyf NK cells-AIDS - Public Health Agency of Canada/ Univ. of Manitoba, Winnipeg - IMRIC Mandelboim Plummer Diabetes Research – University of Alberta, Edmonton - IMRIC Dor Shapiro Cancer Microenvironment – McGill University, Montreal- IMRIC Ben-Porath Batist

  20. Collaborations with Canadian Institutions Parkinson’s disease – Toronto University Hospital - IMRIC BergmanLozano Negative transcriptional regulation– Cancer Research – University of Toronto - IMRIC ParoushLipshitz Epilepsy– University of Toronto - IMRIC Yaari Carlen Osteoporosis – University of Western Ontario - IMRIC Bar-Shavit Dixon

  21. Collaboration Basic / Clinical Research The HadassahUniversity Hospital

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