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Cream Formulation

Cream Formulation

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Cream Formulation

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  1. Cream Formulation Kausar Ahmad Kulliyyah of Pharmacy http://staff.iium.edu.my/akausar PHM4153 Dosage Design 2 2011/12

  2. Contents PHM4153 Dosage Design 2 2011/12

  3. Examples of Creams PHM4153 Dosage Design 2 2011/12

  4. Formulation PHM4153 Dosage Design 2 2011/12

  5. Ideal formulation PHM4153 Dosage Design 2 2011/12

  6. Formulation requirement: efficacy, safety, and quality PHM4153 Dosage Design 2 2011/12

  7. Factors to be considered in formulation PHM4153 Dosage Design 2 2011/12

  8. Choice of vehicle PHM4153 Dosage Design 2 2011/12

  9. Examples of Oils & Fats PHM4153 Dosage Design 2 2011/12

  10. Advantages of Silicones PHM4153 Dosage Design 2 2011/12

  11. Examples of Lipids PHM4153 Dosage Design 2 2011/12

  12. Choosing Oils Properties Limitation PHM4153 Dosage Design 2 2011/12 Emollient effect Shine Lubricity Spreadability Solvency Drying Odour Colour Viscosity Miscibility with other oils Toxicity Impurities Cost

  13. Polarity of oils Non-polar Polar PHM4153 Dosage Design 2 2011/12 Lasting emollient effect Barrier effect Inert Stable against oxidation Shine Spreadability cheap Varying emollient effect Little barrier effect Varying stability against oxidation Good absorption Good delivery expensive

  14. Excipients PHM4153 Dosage Design 2 2011/12

  15. Categories of excipients PHM4153 Dosage Design 2 2011/12

  16. Choosing excipients PHM4153 Dosage Design 2 2011/12

  17. Emulsifiers PHM4153 Dosage Design 2 2011/12

  18. Penetration enhancers • Increase delivery of active substance by: PHM4153 Dosage Design 2 2011/12

  19. Hydration Q. How does urea moisturise the skin? PHM4153 Dosage Design 2 2011/12

  20. PHM4153 Dosage Design 2 2011/12

  21. PHM4153 Dosage Design 2 2011/12

  22. pH adjustment PHM4153 Dosage Design 2 2011/12

  23. Preservatives PHM4153 Dosage Design 2 2011/12

  24. Anti-oxidant PHM4153 Dosage Design 2 2011/12

  25. UV filters PHM4153 Dosage Design 2 2011/12

  26. Other types of excipients PHM4153 Dosage Design 2 2011/12

  27. Effects of excipients PHM4153 Dosage Design 2 2011/12

  28. Physicochemical properties PHM4153 Dosage Design 2 2011/12

  29. Physical and chemical properties of excipients PHM4153 Dosage Design 2 2011/12

  30. Polyamide: Carrier for insoluble ingredients; Protector for sensitive ingredients; Slow delivery & long lasting effect 7 m, empty spheres 10 m, porous PHM4153 Dosage Design 2 2011/12

  31. Excipient: Particle size distribution PHM4153 Dosage Design 2 2011/12

  32. Excipient: Pore volume & pore diameter PHM4153 Dosage Design 2 2011/12

  33. Incompatibility PHM4153 Dosage Design 2 2011/12

  34. Detection of Incompatibility PHM4153 Dosage Design 2 2011/12

  35. Effect of type of preparation: Absorption of retinylpalmitate Exercise: 18% absorbed from acetone vehicle compared to only 4% absorbed from o/w emulsion • WHY? PHM4153 Dosage Design 2 2011/12

  36. Exercise: Determine functions of excipients Nizoral cream Ketoconazole PPG Stearyl alcohol Cetyl alcohol Sorbitanstearate Polysorbate Isopropyl myristate Sodium sulfite Purified water Elomet cream 0.1% Mometasonefuroate White petrolatum White wax PPG stearate Stearyl alcohol Ceteareth-20 Hexylene glycol Titanium dioxide Al starch octenylsuccinate Purified water Phosphoric acid PHM4153 Dosage Design 2 2011/12

  37. References Bugay, D. E. (1999). Pharmaceutical excipients : characterization by IR, Raman, and NMR spectroscopy.RS201E87B931P Kibbe, A. H. (2000). Handbook of pharmaceutical excipients.RS201E87H236K Rowe, R. C., Sheskey, P. J. & Owen, S. C. (2006). Handbook of pharmaceutical excipientsRS201E87H236K Rowe, R. C. (2009). Handbook of pharmaceutical excipients. RS201E87H236K PHM4153 Dosage Design 2 2011/12

  38. Some materials sourced from the following: http://www.eastman.com/Markets/Pharmaceutical/Excipients/Excipients_intro.asp http://www.pharmaceutical-technology.com/contractors/materials/uniqema/ http://www.pformulate.com/ http://images.vertmarkets.com/CRLive/files/Downloads/89FB7970-7376-44A0-B6B6-4B171E4B978B/InsolubleKollidon.pdf Thank you to contributors. PHM4153 Dosage Design 2 2011/12