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Michael Chang | Ashok Ilankovan | Stephanie Pan | Patric Prado | Alyssa Rios

Michael Chang | Ashok Ilankovan | Stephanie Pan | Patric Prado | Alyssa Rios. Faculty Advisor: Professor Konofagou. March 12, 2009. Design Problem and Brief. The Problem: Spinal Muscular Atrophy (SMA): a genetic disease that attacks the motor neurons and leads to muscle weakness and atrophy.

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Michael Chang | Ashok Ilankovan | Stephanie Pan | Patric Prado | Alyssa Rios

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  1. Michael Chang | Ashok Ilankovan | Stephanie Pan | Patric Prado | Alyssa Rios Faculty Advisor: Professor Konofagou March 12, 2009

  2. Design Problem and Brief The Problem: • Spinal Muscular Atrophy (SMA): a genetic disease that attacks the motor neurons and leads to muscle weakness and atrophy. • Current evaluations are subjective, inaccurate, and insensitive. • Clinicians need a robust, quantitative motion analysis system. Our Solution: • Quantify intentional movements • Reliably acquire data • Provide intuitive feedback to clinicians

  3. Design Requirements • Work for different patient body types • Light-weight • Minimize friction • Allow freedom of motion • Support the patient’s arm • Intuitive output

  4. OptEval 2D:1stPrototype Advantages • 3D Printing Material • Nylon ball bearings (4) • Optical Mice (2) • Acrylic Foam Support

  5. OptEval 2D:1stPrototype Drawbacks • Height of device • Sensors insensitive to small movements • Robustness of ball bearings • Bulkiness of arm piece • Weight of material (~2 kg)

  6. OptEval 2D:2ndPrototype Advantages • Laser mice sensors • Delrin ball bearings • Arm rests closer to surface • More compact and lighter • Acrylic structure

  7. OptEval 2D:2ndPrototype Drawbacks • Too small, may not fit all patients • Delrin ball bearings require more weight to roll

  8. Demonstration

  9. Displacement Acceleration Velocity

  10. Improve 2nd Prototype Test Consistency / Calibrate Mouse IRB approval Optimization / Output / Clinical Trials Implement distance sensor March April May Future Work Incorporate GUI for both arms Fabricate 2nd arm piece Refine GUI for one arm

  11. Summary • Goal • Objectively quantify the 2D motions of SMA patients • Milestones • 1st Prototype • Advantage: Easy to move • Disadvantage: Bulky • 2nd Prototype • Advantage: Wireless Mice • Disadvantage: Ball bearings slide • Future Work • Improving 2nd prototype • Optimization of design • Further testing

  12. Acknowledgements Elizabeth Hillman, PhD Assistant Professor of Biomed. Eng. Columbia University Elisa Konofagou, PhD Assistant Professor of Biomed. Eng. Columbia University Gordana Vunjak-Novakovic, PhD Professor of Biomed. Eng. Columbia University Petra Kaufmann, MD Assistant Professor of Neurology Associate Director, Pediatric MDA NeuromuscularClinic Keith Yeager Senior Staff Associate, Lab Manager Columbia University Jacqueline Montes Clinical Coordinator, Physical Therapist Pediatric MDA Neuromuscular Clinic Brenda Chen Teaching Assistant Tim Martens Associate Research Scientist, Department of Surgery

  13. Questions?

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