Developing and Refining the Taiwan Birth Cohort Study(TBCS): Five years of experience

1. 國防醫學院公共衛生學系暨研究所 101學年度第1學期「心理健康」系列專題演講 Developing and Refining the Taiwan Birth Cohort Study(TBCS): Five years of experience 臺北市立聯合醫院 松德院區 龍佛衛 院長 2012-09-17

2. 龍佛衛 院長 • 主要學歷 • 專業經歷

3. 專業領域 • 精神醫學、精神疾病遺傳流行病學、生物統計 • 主要研究方向 • 建立社區精神醫療網 • 精神醫療模式多元化及社區化，結合居家照護、社區復健中心以及康復之家，服務對象包含精神分裂症患者、智能障礙兒童、以及其他慢性精神疾病患者。 • 持續追踪精神疾病之預防醫學及處遇方針 • 對各種不同疾患及族群做相關研究，利用結構方程模式(Structural Equation Modeling; SEM)以及Receiver operating characteristic (ROC)等統計方法來找出潛在危險因子以及篩選指標。 • 研究精神遺傳流行病學 • 針對某些疾患與基因進行研究，如阿茲海默症與Apolipoprotein E有其相關性，尤其是Apoε2及Apoε4；而憂鬱症則與單胺氧化酶基因(MAOA gene)有相關連等等。遺傳與環境的交互作用，基因之變異與較差之環境可能會引發疾病的發病。 • 與台灣其他教學醫院合作研究“出生世代”及“精神疾病患者戒煙計畫”，以及與國際大學合作研究“自閉症、精神分裂症患者之社區治療模式” • 參與國民健康局推動之台灣出生世代之研究。自2003年開始進行前置作業，2005年開始正式研究。我們以“嬰幼兒發展量表”持續追蹤此世代的兒童至目前五歲。

4. Publications • Chi-Fa Hung, For-Wey Lung, Tai-Hsin Hung, Mian-Yoon Chong, Ching-Kuan Wu, Jung-Kwang Wen, Pao-Yen Lin (in press). Monoamine oxidase A gene polymorphism and suicide: An association study and meta-analysis. Journal of Affective Disorders. • For-Wey Lung, Ting-Hsuan Lee, Mei-Feng Huang (in press). Parental bonding in males with adjustment disorder and hyperventilation syndrome. BMC Psychiatry. Corresponding • Pinchen Yang, For-Wey Lung, Cheng-Fang Yen, Shyh-Shin Chiou, Jong-Ling Fuh (in press). Quality of life in methylphenidate treatment-responsive adolescents with attention-deficit/hyperactivity disorder. Kaohsiung Journal of Medical Sciences. • SC Liao, WJ Chen, MB Lee, FW Lung, TJ Lai, CY Liu, CY Lin, MJ Yang, CC Chen (in press). Low Prevalence of Major Depressive Disorder in Taiwanese Adults: Possible Explanations and Implications. Psychological Medicine. • Ben-Chih Yuan, Rong-Feng Chen, Kun-Wei Hsieh, Chen-Tung Lin, Ming-Chang Yang, For-Wey Lung (2012). NOS1 intron20 AAT polymorphism confers vulnerability to mite-induced allergic rhinitis in Chinese population. Journal of Investigational Allergology and Clinical Immunology. Corresponding • Bih-Ching Shu,For-Wey Lung, Ching-Hsien Chen (2011). Mental health of female foreign spouses in transnational marriages in southern Taiwan. BMC Psychiatry, 11, 4-12.Corresponding • Chi-Fa Hung, For-Wey Lung, Chien-Hsiun Chen, Elizabeth O’Nions, Tai-Hsin Hung, Mian-Yoon Chong, Ching-Kuan Wu, Jung-Kwang Wen, Pao-Yen Lin (2011). Association between suicide attempt and a tri-allelic functional polymorphism in serotonin transporter gene promoter in Chinese patients with schizophrenia. Neuroscience Letters, 504, 242-246. • Chia-Chang Chien, Hsien-Te Huang, For-Wey Lung, Chi-Hung Lin (2011). Zolpidem withdrawal delirium, seizure, and acute psychosis: Case reports and literature review. Journal of Substance Use, 116(4), 330-338. • For-Wey Lung, Bih-Ching Shu (2011). Sleeping position and health status of children at six-, eighteen- and thirty-six-month development. Research in Developmental Disabilities, 32, 713-718. • For-Wey Lung, Bih-Ching Shu, Tung-Liang Chiang, Shio-Jean Lin (2011). Maternal mental health and childrearing context in the development of children at 6, 18, and 36 months: A Taiwan birth cohort pilot study. Child: Care, Health and Development, 37(2), 211-223. • For-Wey Lung, Dong-Sheng Tzeng, Mei-Feng Huang, Ming-Been Lee (2011). Association of the MAOA Promoter uVNTR Polymorphism with Suicide Attempts in Patients with Major Depressive Disorder. BMC Medical Genetics, 12(1), 74-84. • For-Wey Lung,Ming-Chang Yang, Bih-Ching Shu (2011). The interleukin-10 promoter haplotype ACA and the long-form variant of the DRD4 uVNTR polymorphism are associated with vulnerability to schizophrenia. Psychiatry Research, 188(2), 294-296. Corresponding • For-Wey Lung, Tung-Liang Chiang, Shio-Jean Lin, Bih-Ching Shu (2011). Autism-risk screening in the first 3 years of life in Taiwan Birth Cohort Pilot Study. Research in Autism Spectrum Disorders, 5, 1385-1389. • For-Wey Lung, Tung-Liang Chiang, Shio-Jean Lin, Bih-Ching Shu, Meng-Chih Lee (2011). Developing and refining the Taiwan Birth Cohort Study (TBCS): Five years of experience Research in Developmental Disabilities. Research in Developmental Disabilities. • For-Wey Lung, Tung-Liang Chiang, Shio-Jean Lin, Jui-Ying Feng, Po-Fei Chen, Bih-Ching Shu (2011). Gender differences of children’s developmental trajectory from six to sixty months in the Taiwan Birth Cohort Pilot Study. Research in Developmental Disabilities, 32, 100-106. • Hui-Ju Wen, Ying-Jan Wang, Ying-Chu Lin, Chih-Chin Chang, Chi-Chang Shieh, For-Wey Lung, Yue Leon Guo (2011). Prediction of atopic dermatitis in 2-yr-old children by cord blood IgE, genetic polymorphisms in cytokine genes, and maternal mentality during pregnancy. Pediatric Allergy and Immunology, 22(7), 695-703. • Hung-Yu Lin, Chun-Hsiung Huang, Tsan-Jung Yu, Wen-Jen Wu, Ming-Chang Yang, For-Wey Lung (2011). p53 Codon72 Polymorphism was Associated with Vulnerability, Progression, but Not Prognosis of Bladder Cancer in Taiwanese Population: A Implication of Structural Equation Modeling to Manage Risks of Bladder Cancer. Urologia Internationalis, 86(3), 355-360. Corresponding • Jui-Kang Tsai, Wen-Kuo Lin, For-Wey Lung (2011). Social interaction and drug attitude effectiveness in patients with schizophrenia. Psychiatric Quarterly. Corresponding • Lii-Shung Huang, Chi-Hwa Yen, Shu-Hsin Lee, Bih-Ching Shu, For-Wey Lung, Ching-Pyng Kuo, Wei-Ya Wu,Angel Yen-Chiao Lu, Yen-Ju Lin, Hui-Sheng Lin, Ming-Chih Chou, Meng-Chih Lee (2011). The pregnancy health and birth outcomes of women who underwent Assisted Reproductive Technology (ART): Results of a national survey. Iranian Journal of Reproductive Medicine, 9(4), 269-276. • Ming-Chang Yang, For-Wey Lung (2011).Neuroprotection of Paliperidone on SH-SY5Y cells against b-Amyloid Peptide25–35, N-methyl-4-phenylpyridinium ion and hydrogen peroxide-induced cell death. Psychopharmacology. Corresponding

5. MTM Lee, CH Chen, CS Lee, CC Chen, MY Chong, WC Ouyang, NY Chiu, LJ Chuo, CY Chen, HKL Tan, HY Lane, TJ Chang, CH Lin, SH Jou, YM Hou, J Feng, TJ Lai, CL Tung, TJ Chen, CJ Chang, FW Lung, CK Chen, IS Shiah, CY Liu, PR Teng, KH Chen, LJ Shen, CS Cheng, TP Chang, CF Li, CH Chou, CY Chen, KHT Wang, CSJ Fann, JY Wu, YT Chen, ATA Cheng (2011). Genome-wide association study of bipolar I disorder in the Han Chinese population. Molecular Psychiatry, 16, 548-556. • Pinchen Yang, Yuh-Jyh Jong, Hsiu-Yi Hsu, For-Wey Lung (2011). Role of assessment tests in the stability of intelligence scoring of preschool children with uneven/delayed cognitive profile. Journal of Intellectual Disability Research, 55(5), 453-461. Corresponding • Po-Fei Chen, Cheng-Sheng Chen, Cheng-Chung Chen, For-Wey Lung (2011). Alexithymia as a screening index for male conscripts with adjustment disorder. Psychiatric Quarterly, 82(2), 139-150. Corresponding • Wei-Jen Chen, Cheng-Chung Chen, Chi-Kung Ho, Frank Huang-Chih Chou, Ming-Been Lee, For-Wey Lung, Guei-Ging Lin, Ching-Yun Teng, Yi-Ting Chung, Ying-Chuan Wang, Feng-Ching Sun (2011). The relationships between quality of life, psychiatric illness, and suicidal ideation in geriatric veterans living in a Veterans’ Home: A structural equation modeling approach. The American Journal of Geriatric Psychiatry, 19(6), 597-601. • Yi-Ching Lu, For-Wey Lung (2011). Perceived parental attachment, personality characteristics and cognition in male incest. International Journal of Offender Therapy and Comparative Criminology. Corresponding • Yi-Chuen Chen, Yi-Ching Lu, For-Wey Lung (2011). Confirmatory factor analysis in neurophysiological and neuropsychological dimensions of schizophrenia. The International Journal of Neuroscience, 121(9), 528-535. Corresponding • Chen-Lin Chang, Dong-Sheng Tzeng, For-Wey Lung (2010). Treatment effectiveness and adherence in patients with schizophrenia treated with risperidone long-acting injection. Psychiatry Research, 180(1), 16-19. Corresponding • Chia-Chang Chien, Chi-Hung Lin, Yong-Yuan Chang, For-Wey Lung (2010). Association of VNTR polymorphisms in the MAOA promoter and DRD4 exon 3 with heroin dependence in male Chinese addicts. The World Journal of Biological Psychiatry, 11(2), 409-416. Corresponding • For-Wey Lung (2010). To be renaming the term of “Schizophrenia”? The question of “to be” or “not to be”. Taiwanese Journal of Psychiatry, 24(3), 161-163. Corresponding • For-Wey Lung, Tung-Liang Chiang, Shio-Jean Lin, Meng-Chih Lee, Bih-Ching Shu (2010). Child developmental screening instrument from six to thirty-six months in Taiwan Birth Cohort Study. Early Human Development, 86, 17-21. • For-Wey Lung, Bih-Ching Shu, Tung-Liang Chiang, Shio-Jean Lin (2010). Parental concerns based General Developmental Screening Tool and Autism risk: the Taiwan national Birth Cohort Study. Pediatric Research, 67(2), 226-231. • Mei-Feng Huang, Cheng-Fang Yen, For-Wey Lung (2010). Moderators and mediators among panic, agoraphobia symptoms and suicidal Ideation in patients with Panic Disorder. Comprehensive Psychiatry, 51(3), 243-249. Corresponding • Pinchen Yang, Bih-Ching Shu, Joachim Franz Hallmayer, For-Wey Lung (2010). Intronic SNPs of Engrailed 2 (EN2) Modulate Disease Vulnerability of Autism in a Han Chinese Population. Neuropsychobiology, 62(2), 104-115. Corresponding • Pinchen Yang, For-Wey Lung, Yuh-Jyh Jong, Hsiu-Yi Hsu, Cheng-Chung Chen (2010). Stability and change of cognitive attributes in children with uneven/delayed cognitive development from preschool through childhood. Research in Developmental Disabilities, 31(4), 895-902. • Ting-Sheng Chung, For-Wey Lung, Dong-Sheng Tzeng (2010). Monoamine Oxidase A Polymorphism, Gender, and Smoking as Predictors for Treatment Respose in Olanzapine-treated patients with Schizophrenia. Taiwanese Journal of psychiatry, 24(4), 291-300. Corresponding • Yung-Li Ku, Yong-Yuan Chang, Tze-Chun Tang, For-Wey Lung (2010). Test of the relationships among different cognitive factors in Beck’s Cognitive Model of depression. Chinese Journal of Psychology, 52(1), 1-10. • Chi-Hung Lin, Yong-Yuan Chang, For-Wey Lung (2009). Sex-specific interaction between MAOA promoter polymorphism and Apo ε2 allele in major depressive disorder in the Chinese population (Letter). Psychiatric Genetics, 19, 337. Corresponding • Chia-Chang Chien, Shu-Fen Huang, For-Wey Lung (2009). Maximally efficient two-stage screening: Determining intellectual disability in Taiwanese military conscripts. Journal of Multidisciplinary Healthcare, 2, 39-44. Corresponding • Dong-Sheng Tzeng, Chai-Chang Chien, For-Wey Lung, Chun-Yuh Yang (2009). MAOA gene polymorphisms and response to mirtazapine in major depression. Human Psychopharmacology: Clinical and Experimental, 24(4), 293-300. • Dong-Sheng Tzeng, Wei-Ching Chung, Pao-Luo Fan, For-Wey Lung, Chun-Yuh Yang (2009). Psychological morbidity, quality of life and their correlations among military health care workers in Taiwan. Industrial Health, 47(6), 626-634.

6. For-Wey Lung, Bih-Ching Shu, Po-Fei Chen (2009). Personality and emotional response in schizophrenics with persistent auditory hallucination. European Psychiatry, 24(7), 470-475. Corresponding • For-Wey Lung, Bih-Ching Shu, Tung-Liang Chiang, Po-Fei Chen, Li-Ling Lin (2009). Predictive validity of Bayley Scale in language development of children at 6-36 months. Pediatrics International, 51(5), 666-669. • For-Wey Lung, Bih-Ching Shu, Wei-Tsung Kao, C. Nathan Chen, Yu-Chi Ku, Dong-Sheng Tzeng (2009). Association of DRD4 uVNTR and TP53 codon72 polymorphisms with schizophrenia: a case-control study. BMC Medical Genetics, 10, 147-154. Corresponding • For-Wey Lung, Chun-Lin Liu, Chien-Shu Wang, Dong-Sheng Tzeng (2009). Adjunctive topiramate treatment for a refractory familial adolescent mania. World Journal of Biological Psychiatry, 10(1), 74-77. Corresponding • For-Wey Lung, Bih-Ching Shu, Tung-Liang Chiang, Shio-Jean Lin (2009). Parental mental health, education, age at childbirth and child development from six to 18 months. Acta Paediatrica, 98(5), 834-841. • For-Wey Lung, Tung-Liang Chiang, Shio-Jean Lin, Bih-Ching Shu (2009). Parental mental health and child development from six to thirty-six months in a birth cohort study in Taiwan. Journal of Perinatal Medicine, 37(4), 397-402. • For-Wey Lung, Tung-Liang Chiang, Shio-Jean Lin, Bih-Ching Shu (2009). Twin-singleton influence on infant development: A national birth cohort study. Child Care Health and Development, 35(3), 409-418. • For-Wey Lung, Yi-Ching Lu, Yong-Yuan Chang, Bih-Ching Shu (2009). Mental symptoms in different health professionals during the SARS sttack: A follow-up study. Psychiatric Quarterly, 80(2), 107-116. Corresponding • Yi-Lung Chen, Ting, Ting-Sheng Cheng, For-Wey Lung (2009). Prolactin levels in olanzapine treatment correlate with positive symptoms of schizophrenia: results from an open-label, flexible-dose study. The Primary Care Companion to the Journal of Clinical Psychiatry, 11(1), 16-20. Corresponding • Chi-Hung Lin, Hsien-Te Huang, Chia-Chang Chien, Dong-Sheng Tzeng, For-Wey Lung (2008). Purple urine bag syndrome in nursing homes: Ten elderly case reports and a literature review. Clinical Interventions of Aging, 3(4), 729-734. Corresponding • For-Wey Lung, Bih-Ching Shu, Tung-Liang Chiang, Shio-Jean Lin (2008). Efficient developmental screening instrument for 6- and 18-month-old children in the Taiwan Birth Cohort pilot Study. Acta Paediatrica, 97(8), 1093-1098. • For-Wey Lung, Chang-Sheng Ku, Wei-Tsung Kao (2008). Telomere length may be associated with hypertension. Journal of Human Hypertension, 22(3), 230-232. Corresponding • For-Wey Lung, Chih-Tao Cheng, Wei-To Chang, Bih-Ching Shu (2008). Anxiety and mood disorder of young males with mitral valve prolapse. Journal of Multidisciplinary Healthcare, 1, 89-92. • For-Wey Lung, Ming-Been Lee (2008).The five-item Brief-Symptom Rating Scale as a suicide ideation screening instrument for psychiatric inpatients and community residents. BMC Psychiatry, 8, 53-60. • For-Wey Lung, Wei-To Chang, Wei-Tsung Kao (2008). Angiotensinogen M235T associated with mitral valve prolapse in young Han Chinese. The American Journal of the Medical Sciences, 336(3), 237-240. Corresponding • Hsin-Yi Peng, Yu-Chi Ku, Bih-Ching Shu, For-Wey Lung (2008). Association between interleukin-10 gene promoter haplotype and schizophrenia in a Han-Chinese Study. International Journal of Biomedical Science, 4(3), 185-191. Corresponding • Hung-Yu Lin, Chun-Hsiung Huang, Wen-Jen Wu, Li-Ching Chang, For-Wey Lung (2008). TP53 codon72 Gene Polymorphism Paradox in Associated with Various Carcinoma Incidences, Invasiveness and Chemotherapy Responses. International Journal of Biomedical Science, 4(4), 248-254. Corresponding • Pinchen Yang, For-Wey Lung, Yuh-Jyh Jong, Hsin-Yi Hsieh, Chung-Ling Liang, Suh-Hang Hank Juo (2008). Association of the homeobox transcription factor gene ENGRAILED 2 (EN2) with autistic disorder in Chinese children. Neuropsychobiology, 57(1-2), 3-8. • Shu-Ying Hou, Chiao-Li Khale Ke, Yi-Ching Su, For-Wey Lung, Chun-Jen Huang (2008). Exploring the burden of the primary family caregivers of patients with schizophrenia in Taiwan. Psychiatry and Clinical Neurosciences, 62(5), 508-514. • Wei-Tsung Kao, Yung-Chieh Yen, For-Wey Lung (2008). The effects of ß2 adrenergic receptor gene polymorphism in lipid profiles. Lipids in Health and Disease, 7(1), 20. Corresponding