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ADME WorkBench Status, Plans, Current Applications (What’s New?)

ADME WorkBench Status, Plans, Current Applications (What’s New?). September 17, 2013 Conrad Housand chousand@aegistg.com support@admewb.com , www.admewb.com. Agenda. Introduction We intend for this to become a monthly user’s group meeting (but non-users are welcome to attend)

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ADME WorkBench Status, Plans, Current Applications (What’s New?)

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  1. ADME WorkBenchStatus, Plans, Current Applications(What’s New?) September 17, 2013 Conrad Housand chousand@aegistg.com support@admewb.com, www.admewb.com

  2. Agenda • Introduction • We intend for this to become a monthly user’s group meeting (but non-users are welcome to attend) • We’ll review newly added features from the previous month • We’ll describe the status of features currently in development, and their estimated availability date • We’ll talk about upcoming events • We’ll present user research and applications • We’ll listen to feedback from customers and the ADME community

  3. New Features • Gut metabolism • Scale from intestinal microsomes (linear/saturable) • Scale from liver microsomes (linear/saturable) • Gut transporters • Influx/efflux based in total microsomal abundance (linear/saturable) • Influx/efflux based on microsomal abundance relative to illeum/Caco2 (linear/saturable)

  4. New Features • Saturable renal clearance • Tubular secretion/reabsorption • Externally-defined absorption rate • Imported tabular absorption rate vs. time data • User-defined model parameters • Additions to user interface and project database • Provides “hook” to custom code in PBPK model

  5. In Development • Additional target species • Rabbit, monkey, guinea pig • User-defined PBPK tissues • User-specified physiological parameters • Variability • Basic physiological parameters • Age dependence • Basic physiological parameters, some metabolism

  6. In Development • Advanced inhalation model • Gloede + additions for particulate deposition and dissolution • Metabolites • Parallel PBPK models to track parents/metabolites • Metabolism in multiple tissues: gut, liver to start

  7. In Development • Examples • Midazolam w/ transporters • Dermal absorption • Externally-supplied flux • Thanks to John Troutman, P&G

  8. In Development • Next webinar in October • http://www.admewb.com/webinars/ • http://www.admewb.com/webinars/ • October 22: http://bit.ly/16biFZf • October 24: http://bit.ly/1f08Ghq

  9. Thank you Questions? Thank you!

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