Download
dceg studies and biospecimen management n.
Skip this Video
Loading SlideShow in 5 Seconds..
DCEG Studies and Biospecimen Management PowerPoint Presentation
Download Presentation
DCEG Studies and Biospecimen Management

DCEG Studies and Biospecimen Management

156 Vues Download Presentation
Télécharger la présentation

DCEG Studies and Biospecimen Management

- - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

  1. DCEG Studies andBiospecimen Management Jim Vaught, Ph.D. Special Assistant for Biological Resources Division of Cancer Epidemiology & Genetics

  2. Division of Cancer Epidemiology & Genetics (DCEG) “..a national program for population-based studies to identify environmental and genetic determinants of cancer.” • Biostatistics Branch • Environmental Epidemiology Branch • Genetic Epidemiology Branch • Nutritional Epidemiology Branch • Occupational Epidemiology Branch • Radiation Epidemiology Branch • Viral Epidemiology Branch

  3. DCEG Biorepository Program • ~7,000,000 biospecimens in inventory • Over 450 studies with specimen collections – directed by about 60 DCEG PIs • Biorepository support contracts: collection, bioprocessing, storage, shipping • Bioprocessing: blood processing, cryopreservation, aliquoting, DNA extraction, biomarker assays • Emphasis on quality control & growth management

  4. DCEG Contract Biorepository

  5. DCEG Biorepositories

  6. Examples from among 80+ specimen types in DCEG biorepositories

  7. DCEG Biorepositories – more specimen types

  8. Specimens for Molecular Epidemiology Studies • Micronutrients – vitamins, carotenoids, fats • Genotyping, DNA sequencing • Mutation analyses • Virus detection - HPV, HHV, HIV • Pesticides & PCBs • Polycyclic hydrocarbons • Water contaminants • Endogenous hormone assays • Insulin-like growth factors

  9. Genotyping for DCEG studies • DNA extraction - ~80,000 specimens during 2002-2003 at contract labs • Genotyping - ~35,000 samples from about 25 studies, total of ~1,000,000 assays requested at CGF • Additional DCEG studies approved for genotyping either at CGF or by commercial vendor