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DCEG Studies and Biospecimen Management

DCEG Studies and Biospecimen Management. Jim Vaught, Ph.D. Special Assistant for Biological Resources Division of Cancer Epidemiology & Genetics. Division of Cancer Epidemiology & Genetics (DCEG).

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DCEG Studies and Biospecimen Management

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  1. DCEG Studies andBiospecimen Management Jim Vaught, Ph.D. Special Assistant for Biological Resources Division of Cancer Epidemiology & Genetics

  2. Division of Cancer Epidemiology & Genetics (DCEG) “..a national program for population-based studies to identify environmental and genetic determinants of cancer.” • Biostatistics Branch • Environmental Epidemiology Branch • Genetic Epidemiology Branch • Nutritional Epidemiology Branch • Occupational Epidemiology Branch • Radiation Epidemiology Branch • Viral Epidemiology Branch

  3. DCEG Biorepository Program • ~7,000,000 biospecimens in inventory • Over 450 studies with specimen collections – directed by about 60 DCEG PIs • Biorepository support contracts: collection, bioprocessing, storage, shipping • Bioprocessing: blood processing, cryopreservation, aliquoting, DNA extraction, biomarker assays • Emphasis on quality control & growth management

  4. DCEG Contract Biorepository

  5. DCEG Biorepositories

  6. Examples from among 80+ specimen types in DCEG biorepositories

  7. DCEG Biorepositories – more specimen types

  8. Specimens for Molecular Epidemiology Studies • Micronutrients – vitamins, carotenoids, fats • Genotyping, DNA sequencing • Mutation analyses • Virus detection - HPV, HHV, HIV • Pesticides & PCBs • Polycyclic hydrocarbons • Water contaminants • Endogenous hormone assays • Insulin-like growth factors

  9. Genotyping for DCEG studies • DNA extraction - ~80,000 specimens during 2002-2003 at contract labs • Genotyping - ~35,000 samples from about 25 studies, total of ~1,000,000 assays requested at CGF • Additional DCEG studies approved for genotyping either at CGF or by commercial vendor

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