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excitatory phenomena during induction of general anaesthesia: a molecular or dynamic explanation

Weird things happen in the Twilight Zone. Restlessness, Delirium, Limb

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excitatory phenomena during induction of general anaesthesia: a molecular or dynamic explanation

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    1. Excitatory phenomena during induction of General Anaesthesia: a Molecular or Dynamic explanation? JW Sleigh1, M Steyn-Ross2, DA Steyn-Ross2 1Department of Anaesthetics, Waikato Clinical School, University of Auckland, Hamilton, NZ 2Department of Physics and Engineering, University of Waikato, Hamilton, NZ

    2. Weird things happen in the Twilight Zone Restlessness, Delirium, Limb & eye Movements, Irregular respiration and Laryngospasm, Vomiting, EEG excitation, ANS activity

    3. Explanations of Excitation? MOLECULES? Drugs acting on different ‘receptors’ NEURONS? Inhibition of the inhibitor cells NEURAL POPULATION? Phase-transition

    5. A Universal Phenomenon ? ? Universal Explanation? [Halsey & Smith (1970)]

    8. Macrocolumn Model Cortex is a collection of inter-connected macrocolumns Cortico-cortico connections Extra-cortical input: Scalp-measured EEG corresponds to ac component of he (mean excitatory soma potential)

    9. EEG Power Surge @ Loss-of-Consciousness“Falls out for free”

    10. Phase-transition – Increasing GA

    11. Critical-Point Phenomena: the “footprints of a phase-transition” Critical “Slowing Down” Increased Spatial Correlations Exaggerated Responses to External Stimuli

    12. John et al : Induction

    13. Why Etomidate >> Thiopentone?

    14. The Twittering Machine. Paul Klee

    16. EEG Activity vs Anaesthetic Concentration.

    17. Predicted/Model “EEG” Spectrum

    18. Clinical EEG: “Biphasic” Peaks

    19. Power Surge:

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