Installation and configuration

1. Installation and configuration Clarity User Training

2. Installation • Software protection • Software installation • HW installation • Software configuration

3. Software Protection • Software protection by hardware key • Hardware key (dongle) required for each station • USB standard (LPT optional on request) • The software is independent of hardware (A/D boards) • User code (16 position alfanumeric code) combined with the apropriate dongle (S/N yyyy) is necessary to operate the Clarity Datastation (S/N xx-zyyyy) • 30 day trial version available IMPORTANT !! Please note that a loss of a dongle (hardware key) is considered as a loss of the license right to use Clarity SW.

4. Software Installation • Install the software first before any hardware! • Insert the CD • Start install.exe (if not started automatically) • Follow the dialog screens Set the installation directory

5. Software Installation Select type of installation Typical should be used in most cases Set the program folder

6. Software Installation Enter the User code corresponding to the HW key used Leave blank for30 day Trial mode Chose acquisition device which would you like to set as default

7. Software Installation Wait for next screen, the installation is in progress

8. Software Installation Start the Hardware installation Wait for next screen, the installation is in progress

9. Software Installation Finish the Hardware installation Wait for the installation to finish

10. Software Installation Finish the software installation Show readme.txt file Run Clarity (do not check with hardware not yet installed!) Run IQ utility

11. Switch off the computer Insert the INT7 A/D board to a free PCI slot Switch on the computer Follow the New Hardware Found dialogs Hardware Installation

12. Hardware Installation Select „No, not this time“ for updates search Select Install Automatically (first time installation on a new computer)

13. Hardware Installation Wait, Installation is in progress This warning may appear under some circumstances. It is safe to ignore it, use „Continue Anyway“ to proceed

14. Insert the HW key New hardware found notice will shortly appear, the installation is automatic Hardware Installation Finish the hardware installation

15. Electric connections • Inputs IN1-IN4 • Symmetric inputs – the shield cable must be connected

16. Clarity First Start Start Clarity using the desktop icon Registration Dialog Needed for on-line updates Click here to open instrument Login Dialog Enter your name

17. Configuration • User Accounts • user access privileges • Configuration • configuration of the datastation • Directories • working directories for individual instruments • Digital Outputs • setting and assignment of digital outputs System/Configuration

18. User Accounts window • To define users • When several operators use the station for different analyses • The desktop file (user profile) stores information about last used project, table and graph settings, last opened files, etc.

19. User Accounts Leave zeros for empty passwords or not restricted password life time. Leave blank for unprotected mode. (All users will share common desktop file) Fill in accordance with your company rules for GLP and 21CFRpart11 compliance User can change his/her password in the User Account Details dialog

20. System Configuration window Setting of displayed instruments(data acquisition allowed only on instruments with purchased licence) Instrument type selection Installed devices Available Control modules Select the digital input and output for synchronisation Selected instrument configuration (add devices)

21. System Configuration window Available Control Modules list Device configuration (doubleclick the device icon)

22. Directories window • Working directories • enables working with data over network • Directory = where the available projects are searched for • Useful for connecting of Eval version from other computer Blank = Clarity instalation directory Blank = LOG subdirectory of Clarity instalation directory

23. Projects • Chromatography data storage according to • user • analysis type • sample type • time

24. File and Folders structure Main Clarity directory program files, configuration, user settings COMMON Subdirectory report styles (*.sty), default method templates, other files shared between projects Projects Subdirectory project files info (*.prj) Project Directory methods (met.*), sequences (seq.*) Project CALIB subdirectory calibration files (cal.*) and standard chromatograms (*.prm) Project DATA subdirectory sample chromatograms (*.prm)

25. Chromatogram files • RAW raw data file • data as received from A/D converter • created at run start and incremented during analysis • actual and last processed stored in TMP subdirectory • PRM primary data • integrated data • created when analysis is finished • contains RAW data, history and copy of calibration file • CAL calibration file • contains data for calibrated results calculations • referenced from method and chromatograms • actual copies stored in saved chromatogram

26. Functionality Check 1) Open Data Acquisition window. The signal will drift if the signal cable wires are free and should be within a few µV from 0 mV if the are interconnected. You can also compare the detector display reading and reaction to autozero. 2) Upon the injection (closing the marker contact) the analysis will start. Data Acquisition window will change in appearance. Note: The optional Validator can be used to check the system correct function