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PRECANCEROUS GASTRIC LESIONS - our Bulgarian experience

PRECANCEROUS GASTRIC LESIONS - our Bulgarian experience. Stefan P. Petrov, MD; PhD St. Ann Hospital, Sofia. 10 – 12 – 2010 SOFIA. The Morphology Point of the History of the Problem 3 points:. 1. Displasia 2. Intestinal Metaplasia 3. Bacteriology – Helicobacter pylori. 1.DISPLASIA - 1.

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PRECANCEROUS GASTRIC LESIONS - our Bulgarian experience

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  1. PRECANCEROUS GASTRIC LESIONS- our Bulgarian experience Stefan P. Petrov, MD; PhD St. Ann Hospital, Sofia 10 – 12 – 2010 SOFIA

  2. The Morphology Point of the History of the Problem 3 points: 1. Displasia2. Intestinal Metaplasia3. Bacteriology – Helicobacter pylori

  3. 1.DISPLASIA - 1

  4. 1.DISPLASIA - 2

  5. 2. INTESTINAL METAPLASIA - 1

  6. 2. INTESTINAL METAPLASIA - 2

  7. 2. INTESTINAL METAPLASIA - 3

  8. 2. INTESTINAL METAPLASIA - 4

  9. 2. INTESTINAL METAPLASIA - 5

  10. 2. INTESTINAL METAPLASIA - 6

  11. 3. THE NEW ERA – BACTERIOLOGY – HELICOBACTER PYLORI

  12. 3. THE NEW ERA – BACTERIOLOGY – HELICOBACTER PYLORI UNIDENTIFIED CURVED BACILLI ON GASTRIC EPITHELIUM IN ACTIVE CHRONIC GASTRITIS UNIDENTIFIED CURVED BACILLI IN THE STOMACH OF PATIENTS WITH GASTRITIS AND PEPTIC ULCERATION BJ Marshall & JR Warren, Dept of Gastroenterology and Pathology, Royal Perth Hospital, Perth, Western Australia The Lancet, june 4, 1983

  13. 3. THE NEW ERA – BACTERIOLOGY – HELICOBACTER PYLORI

  14. 3. THE NEW ERA – BACTERIOLOGY – HELICOBACTER PYLORI

  15. 3. THE NEW ERA – BACTERIOLOGY – HELICOBACTER PYLORI

  16. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 1 Polychromatic Methods 1 – R. Genta (1994) X 400 X 64

  17. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 2 Polychromatic Methods 2 – C. Doglioni (1997) simultaneously identification of the H.P. & Helicobacter Heilmanii X 1000

  18. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 3 Polychromatic Methods 3 – Hala El-Zimaity (1998) simultaneously identification of the H.P. & Intestinal Metaplasia X 400 X 128 X 1000

  19. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 4 Impregnation Methods 1 – AgNOR и H.P.– impregnation ( W.Howell & D. Black /1980/– modificationbyD. Plotton /1984/) simultaneously identification of the H.P. & Proliferative Activity X 400 X 400 X 400

  20. 5. THE NEW ERA – OUR CONTRIBUTION – TREPONEMA PALLIDA - 1 Impregnation Methods 2 – the golden standard – Whartin - Starry (1984) Siphylitic gastropathia – 29 year man X 128 X 400

  21. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 1 Combined Methods 1 – Granofurine – Evans-Blue – Jodasept simultaneously identification of the H.P. & fluorescence (an attempt)

  22. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 1 PATENTED № 202 / 30.07.1998 г. INRA Advantages of application of a yellow filter and simple half-Gram staining for detection of Helicobacter pylori, Modern Pathology, 8; 3, 1995, 339 – 340 pp.

  23. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 2

  24. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 2 i.e. long form of H.P. The First Bulgarian SEM of Helicobacter pylori – 1993 - 1

  25. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 3 2 long form of H.P. The First Bulgarian SEM of Helicobacter pylori – 1993 - 2

  26. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 4 “battle field” in the ulcer border The First Bulgarian SEM of Helicobacter pylori – 1993 - 3

  27. 5. THE NEW ERA – OUR CONTRIBUTION – HELICOBACTER PYLORI - 5 i.e. “cigar shaped” form Of H.P. The First Bulgarian SEM of Helicobacter pylori – 1993 - 4

  28. 6. THE NEW ERA – OUR RESULTS – HELICOBACTER PYLORI - 1 GASTRITES & HELICOBACTER PYLORI - 1

  29. 6. THE NEW ERA – OUR RESULTS – HELICOBACTER PYLORI - 2 GASTRITES & HELICOBACTER PYLORI - 2

  30. 6. THE NEW ERA – OUR RESULTS – HELICOBACTER PYLORI - 3 ALL GASTRIC MALIGNANT TUMORS & HELICOBACTER PYLORI - 1 Fig 3. Helicobacter Heilmanii (4) – 0.496 % from all biopsies and 0.98 from Helicobacter ( + ) – association between both in 25%

  31. 6. THE NEW ERA – OUR RESULTS – HELICOBACTER PYLORI - 4 HELICOBACTER PYLORI in GASTRIC CARCINOMAS (according to Pekka Lauren) - 2

  32. 7. THE NEW ERA – BULGARIAN PATHOLOGY ASSOCIATION (since 2009)

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