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Anti-inflammatory, Anti-arthritic

Anti-inflammatory, Anti-arthritic

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Anti-inflammatory, Anti-arthritic

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  1. FLEXIMUV CAPSULE Anti-inflammatory, Anti-arthritic

  2. TREATMENT Allopathic: Diclofenac, Celecoxib, Rofecoxib, Cyclosporin, D- penicillamine,Methotrexate, Azathioprine Ayurvedic / Herbal: Boswellia serrata (Salai Guggul), Commiphora mukul, Turmeric, Ashwagandha, Nirgundi, Ginger

  3. FLEXIMUV CAPSULE Composition: Each capsule contains: Curcuma longa extract (Turmeric) : 100 mg. Glycyrrhiza glabra extract (Licorice) : 100 mg. Valeriana wallichii powder(Tagar) : 60 mg. Withania somnifera extract (Ashwagandha) : 50 mg. Commiphora mukul extract (Guggul) : 50 mg. Vitex negundo extract (Nirgundi) : 50 mg. Apium graveolens extract (Ajmod) : 50 mg. Trigonella foenum-graecum extract (Methi) : 50 mg. Excipients : q.s. Indications: For relief from inflammatory conditions of Osteoarthritis and Rheumatoid arthritis.

  4. Powerful Antiarthritic Effective in arthritis & spondylosis Analgesic, reduces swelling of joints Antiinflammatory, useful in R.A. Withania somnifera ext. (1.5 % Withanoloides) Trigonella foenum- graecum ext. (20 % Saponins) Vitex negundo ext. (0.15 % Alkaloidsi) Commiphora mukul ext.(2.5 % Guggulsterones) FLEXIMUV CAPSULE (for relief in Osteoarthritis & Rheumatoid arthritis) Valerian powder (Tagar) Curcuma longa ext.(7 % Curcumin) Apium graveolens extract (5 % Volatile oil) Glycyrrhiza glabra ext. (20 % Glycryrrhizin) Non-steroidal Anti-inflammatory, Useful in osteoarthritis Useful in Rheumatoid arthritis & Gout Sedative, to reduce twitching of limbs during sleep Antiinflammtory

  5. Pharmacological studies of Fleximuv Capsule Anti-inflammatory activity: Fleximuv capsule (200 mg/kg) showed 97 % activity as compared to Celecoxib (200 mg/kg.) and 77 % activity as compared to Diclofenac (50 mg/kg.) Analgesic activity: Fleximuv capsule (200 mg/kg) showed 99 % activity as compared to Diclofenac (50 mg/kg.) Ulcerogenic potential: In comparison to Aspirin (500 mg/kg.), Fleximuv showed –16.7 % reduction in ulcer index

  6. Toxicity studies of Fleximuv Capsule • Acute oral toxicity on rats: LD50 as a single dose is more than 2 g/kg. b.w. • Acute oral toxicity on mice: LD50 as a single dose is more than 2 g/kg. b.w. • Sub- Acute oral toxicity on rats: NOAEL level over 28 days was 50 mg/kg b.w. • Sub- Acute oral toxicity on mice: NOAEL level over 28 days was 50 mg/kg b.w.

  7. FLEXIMUV CAPSULE SAFETY & TOLERANCE STUDIES IN HUMAN VOLUNTEERS Total no. of volunteers : 25 Dose : 500 mg. – 2 g. / patient/ day Treatment period : 1 week Results: No adverse or toxic reactions during the study. No significant changes in haematological and biochemical parameters were seen.

  8. CLINICAL TRIALS OF FLEXIMUV CAPSULE Aim of study : To assess the efficacy of Fleximuv capsule in Osteoarthritis of knee Center : M.Y. Hospital, Indore Total no. of patients : 100, fifty in each group Comparitive drug : Rofecoxib Duration of study : 6 weeks Age group : 45 to 70 years Dose : 1 & 2 capsule, twice daily

  9. CLINICAL TRIALS OF FLEXIMUV CAPSULE Parameters for study: • Intensity of pain at rest • Pain on joint use • Tenderness on pressure • Joint swelling • Range of motion of knee • 50 feet walking time • Morning stiffness

  10. CLINICAL TRIALS OF FLEXIMUV CAPSULE RESULTS: Age groupGood /Very good 1 cap. B.D. 2 cap. B.D. 45- 55 years 71.4 % 61 % 56 - 65 years 50 % 57 % 66 – 70 years 33 % 29 % Side effects : Negligible

  11. FLEXIMUV CAPSULE MARKETED AYURVEDIC BRANDS