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Membrane Transport Mechanisms in Small Molecules: Understanding Cellular Permeability and Active vs. Passive Transport

Explore the intricate ways molecules move across lipid bilayers, including permeability, carrier proteins, and channel proteins. Understand the dynamics of passive and active transport driven by electrochemical gradients and membrane potential. Learn about conformational changes in carrier proteins and the mechanisms of carrier-mediated transport. Discover the role of ion channels in membrane potential changes and the propagation of action potentials.

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Membrane Transport Mechanisms in Small Molecules: Understanding Cellular Permeability and Active vs. Passive Transport

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Presentation Transcript

  1. Lecture 4 BIO 344 Chapter 10 and 11

  2. Chapter 11 Membrane Transport of Small Molecules and the Electrical Properties of Membranes

  3. Molecule movement across lipid bilayer without proteins

  4. Permeability across lipid bilayer

  5. Carrier Proteins

  6. Channel Proteins

  7. Passive vs. Active Transport

  8. Three Ways of Driving Active Transport

  9. Electrochemical gradient vs. membrane potential Can work additively or against each other

  10. Three Ways of Driving Active Transport

  11. Conformational Change in Carrier Protein mediates passive transport

  12. Three Types of Carrier Mediated Transport

  13. DVD Clip 43

  14. Mechanism of Na+ - glucose carrier Binding of Na+ and glucose is cooperative

  15. DVD Clip 44

  16. Microvilli in the small intestine

  17. Transcellular transport of glucose

  18. The Na+ - K+ pump is an ATPase

  19. DVD clip 42

  20. Response of red blood cells to changes in osmolarity of extra cellular fluids

  21. Distribution of phospholipids and glycolipids in the lipid bilayer of human red blood cells

  22. Few Ions are required to cause a large change in membrane potential

  23. Electrochemical gradient vs. membrane potential Can work additively or against each other

  24. Selectivity of a K+ channel

  25. DVD Clip 45

  26. Ion Channels fluctuate between closed and open conformations

  27. Gating of K+ channel

  28. Gating of Ion Channels

  29. A Typical Vertebrate Neuron

  30. Ball and Chain Model of Rapid inactivation of ion channel

  31. Propagation of Action Potential

  32. Changes in Na+ channels and the action potential

  33. Changes in Na+ channels and the action potential

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