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Endocrine Disrupting Chemicals (EDCs)

Endocrine Disrupting Chemicals (EDCs). Lafayette College CE 372 Design II/Environmental Site Assessment. Slides provided by Cynthia Gulledge, University of Louisville, Kentucky. Endocrinology: study of hormones. General Features of the endocrine system:. Transport. Gland. Hormone.

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Endocrine Disrupting Chemicals (EDCs)

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  1. Endocrine Disrupting Chemicals (EDCs) Lafayette College CE 372 Design II/Environmental Site Assessment Slides provided by Cynthia Gulledge, University of Louisville, Kentucky

  2. Endocrinology: study of hormones General Features of the endocrine system: Transport Gland Hormone Target Cell rich blood supply hormone receptors are very specific secreted into the blood ductless can reach virtually every cell in the body

  3. Endocrine Glands don’t forget the heart, placenta, fat All of these glands produce hormones and are also targets for hormones

  4. ENDOCRINE SYSTEM HORMONES Chemical Messengers Secreted By Glands (pituitary, ovary, testis, adrenal) Into the Bloodstream

  5. Chemical Confusion • Environmental chemicals can trick or confuse the body into thinking they are natural body chemicals

  6. Symantec Confusion • Endocrine disrupting chemicals (EDCs) • Hormonally-active agents • Environmental estrogens • Environmental hormones • Environmental chemicals • Environmental signaling

  7. Functional or Receptor-Based Toxicology McLachlan, J.A. 2001 Environmental Signaling: What Embryos and Evolution Teach Us About Endocrine Disrupting Chemicals, Endocrine Reviews 22(3): 319-341.

  8. Pesticide application Feedlot runoff (hormones, pharmaceuticals) Plasticizers Industrial solvents, effluent Sewage effluent (hormones, pharmaceuticals) Personal care products (hair and skin care) Pesticide application (lawns, golf courses) Phytoestrogens Sources of Hormonally-Active Compounds Agriculture Industry/Urbanization “Natural”

  9. Sexual Differentiation in Mammals Organizational Effect of Hormones If something goes wrong with testis formation, the rest of sexual differentiation is affected in the male

  10. Infertility / subfertility Feminization Advanced puberty Estrogens, anti-androgens, etc. Sources include agriculture, industry, plants e.g., testicular dysgenesis, infertility, feminization Take-Home Message Reproductive abnormalities in wildlife and humans Many hormonally-active compounds in environment These compounds cause reproductive abnormalities in lab This evidence forms the basis of the endocrine disrupter hypothesis

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