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Regulation of AMPA Receptors via GluR1 Phosphorylation in Long-Term Potentiation

Explore the biochemistry behind LTP regulation of AMPA receptors through GluR1 phosphorylation, focusing on S831 and S845 phosphorylation sites along with their effects on synaptic responses and plasticity in mice.

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Regulation of AMPA Receptors via GluR1 Phosphorylation in Long-Term Potentiation

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  1. BIPN148 Lecture 12

  2. Biochemical Basis of LTP

  3. Regulation of AMPA receptors by phosphorylation

  4. GluR1 phosphorylation at S831

  5. S831 phosphorylation on GluR1 by Cam KII

  6. Phospho-specific antibodies to GluR1

  7. LTP induces S831 phosphorylation

  8. Evidence for GluR1 insertion at synapses

  9. CaMKII effect of synaptic responses

  10. Comparison of S831 (CKII), S845 (PKA)phosphorylations

  11. Effect of S831A, S845A on LTP

  12. Generation of S831/845- mice

  13. Plasticity in S831/845- mice

  14. AMPA receptor phosphorylation

  15. Comparison of S831A, T887A mutationson synaptic responses

  16. Effect of S887A on LTP (PDZ interactor)

  17. Glutamate Receptor Insertion and Stabilization in E-LTP Stabilization Stabilization AMPAR NMDAR NMDAR AMPAR ? 4.1 CaMKII* Membrane insertion Membrane insertion SAP97 PSD-95 actinin src AMPAR NMDAR actin CaMKII PKC* CaMKII* Ca++ trigger for E-LTP * = Autophosphorylated CaMKII, Autonomous PKC

  18. NR2B interaction with CaMKII

  19. NR1 Phosphorylation by CaMKII

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