Mycotoxins in Ruminants for Food Safety 反刍动物霉菌毒素对食品安全的危害 by Scott Fleetwood, Ph.D .

Mycotoxins in Ruminants for Food Safety反刍动物霉菌毒素对食品安全的危害by Scott Fleetwood, Ph.D. Executive Director Global Industry and Government Policy and Affairs 全球产业政策与政府事务执行理事，诺伟司国际公司

A Safe Food Supply Is Critical食品安全是关键 • Consumers must have a high level of trust that the food they eat is safe 消费者必须高度信任他们所吃的食品是安全的 • Outbreaks of food borne diseases damage the reputation of the suppliers in the chain individually and collectively 食源性疾病的爆发损害了食品供应链中个别或者全体供应商的声誉 • Understanding and implementing best practice processes will help ensure a safe food supply and trust with consumers around the world. 理解和实施最佳食品安全生产管理将确保全球性的安全食品供应和消费者信赖

The Novus Story诺伟司故事 • Born in 1991 out of the scientific heritage of Monsanto 成立于1991年，科技源于孟山都公司 • Growing under Mitsui & Co. (USA) Inc. and Nippon Soda Co, Ltd.成长于三井物产（美国）有限公司和日本曹达有限公司 • Multiple Product Families Based on Science 丰富的产品系列均基于科学的研究 • Portfolio Leveraged Across Multiple Species in Global Markets在全球市场跨越多个物种的产品组合 • Team of Industry Experts with Deep Market Knowledge 由具备深厚市场知识的行业专家组成的团队 • Programs Designed to Address Customer ROI & Challenge 旨在满足客户的投资回报率和解决问题的产品方案

The Novus Story诺伟司故事 • Sales totaling 1.1 Billion USD 销售总额近1.1亿美元 • Over 900 employees around the world 全世界有900多名员工 • Conducting business in over 95 countries 业务遍及95个多国家 • Serving more than 2500 customers globally 服务全球2500多名客户

Vision/远景 To help feed the world affordable, wholesome food and achieve a higher quality of life. 为全球提供质优、价廉的健康食品，实现优质生活。 Mission/使命 Make a clear difference in sustainably meeting the growing global needs for nutrition and health. 在可持续满足全球营养和健康需要上，作出显著成绩。 The Novus Story诺伟司故事生产性能动物福利环境保护食品安全

Food Safety Activity in China 中国食品安全行动

Mycotoxin occurrence in feed and feedstuffs of China in 2009中国饲料中的霉菌毒素污染情况,2009

Co-occurrence of mycotoxins in 244 China samples (feed and feedstuffs), 2009244种中国饲料和原料中霉菌毒素污染情况，2009 No mycotoxins detected 1 mycotoxin detected 2 mycotoxins detected 3 mycotoxins detected 4 or more mycotoxins detected

Fact: Some rumen microbes (and protozoa) degrade myxotoxins事实: 反刍动物瘤胃微生物能降解霉菌毒素 BUT HOW MUCH? 但是，降解多少？

Ruminal Detoxification 反刍动物的解毒作用 Natural Bioconversion in the Rumen瘤胃自发的生物转化能力 Jouany and Diaz 2005

Sources of mycotoxins for ruminants反刍动物霉菌毒素的来源 Feed supply - Grain 谷物饲料 - Forage 干草料 - Silage青贮料 - Pasture 牧草 Bedding - Straw 稻草牛舍 - Litter 垫料 Dust 灰尘

Mycotoxin contamination in silage, hay and corn straw samples, China (n=19) 中国青贮料，干草和秸秆霉菌毒素污染调查

Aflatoxin M1 Levels in Lactating Dairy Cattle 哺乳期牛奶中黄曲霉毒素M1水平 Feed : Milk =2% 饲料：牛奶 =2% 去除黄曲霉毒素添加黄曲霉毒素天 Diaz et al. Mycopathologia 2004

China regulation: AFB1limits in feed and feedstuffsGB 13078-2001，ppb中国政府对饲料及原料中黄曲霉毒素B1的浓度限制

China regulation: OTA and ZON limits in feed and cornGB 13078.2 -2006，ppb中国政府对饲料及玉米中赫曲霉毒素和玉米赤霉烯酮的浓度限制

China regulation: DON limits in feedGB 130subtitil78.3 -2008，ppm中国政府对饲料中呕吐毒素的浓度限制

What is a safe level of Mycotoxin? 霉菌毒素的允许含量是多少？ There are NO safe levels 没有允许含量 Risk is dependent on the concentration 霉菌毒素的危害性程度取决于其存在的浓度 Depends on the presence of other mycotoxins 取决于其他霉菌毒素存在与否 17

Mycotoxin management霉菌毒素管理 Mycotoxins are the drop that fills the cup. They showcase deficiencies in production and management programs 霉菌毒素的存在可以反应企业在生产和管理过程中存在的问题 Subclinical losses are also key 无临床症状所造成的损失同样不容忽视 Total nutrition综合营养管理方案 Mineral/vitamin nutrition补充有机微量元素/维生素 Amino Acid nutrition补充氨基酸 Gut health (MOS, Yeast, Organic Acids)维护肠道健康（MOS、酵母、有机酸） Feed quality/stability of nutrients (Vitamin E)确保营养物质的品质/稳定性（维生素E） Link between nutrition and health把营养与健康相结合 18

Thank You! ขอบคุณ Obrigado Merci Благодаря ви 谢谢 mulţumesc Gracias Asante sana cảm ơn lắm

Mycotoxins in Ruminants for Food Safety 反刍动物霉菌毒素对食品安全的危害 by Scott Fleetwood, Ph.D .