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Station 3 – Inhibitor poisons

Example 1 : Snake Venom Inhibitor name : A protein called fasciculation is found in snake venom.

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Station 3 – Inhibitor poisons

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  1. Example 1: Snake Venom Inhibitor name: A protein called fasciculation is found in snake venom. Function: Inhibits Acetylcholinesterase which is an enzyme used to degrade a neurotransmitter called Acetylcholine (Serotinin is another example of a neurotransmitter that you should have heard of from GCSE). How: Fasciculation acts as a competitive inhibitor preventing the acetylcholine from being broken down by Acetylcholinesterase after an impulse transmission. Effect: In skeletal muscle fasciculations stop nerve impulses from being transmitted and hence stop muscle contraction. Eventually this will lead to flaccid paralysis. Normal (no venom) Station 3 – Inhibitor poisons After venom

  2. Example 2: Cyanide poisoning Inhibitor name: Potassium cyanide Function: Inhibits a vital respiratory enzyme called cytochromeoxidase (found inside mitochondria) How: Cytochromeoxidase normally combines oxygen and hydrogen together to form water and allows ATP creation. Station 3 – Inhibitor poisons Cyanide non competitively inhibits chytochromeoxidase changing the shape of its active site meaning no ATP creation. Effect: Any reactions requiring ATP are no longer supplied. The body eventually has no energy supply causing total cell failure … and death even though all products for respiration still present.

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