1 / 7

Vitamin B6

Vitamin B6. Forms:pyridoxal , pyridoxine ,pyridoxamine Active form : PLP (pyridoxal 5’-phosphate) As a coenzyme  amino acid and protein metabolism 1978 &1985 Driskell Elder and adolescent girl  Vit.B6 deficiency risk group 1985 Thanassi Low Vit B6 intake  cancer

maj
Télécharger la présentation

Vitamin B6

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Vitamin B6 • Forms:pyridoxal , pyridoxine ,pyridoxamine • Active form : PLP (pyridoxal 5’-phosphate) • As a coenzyme  amino acid and protein metabolism • 1978&1985 Driskell Elder and adolescent girl Vit.B6 deficiency risk group • 1985 Thanassi Low Vit B6 intake  cancer 1985 Willett Low Vit B6 intake CHD

  2. Vitamin B6 measures • 1.plasma PLP : (1)diet Vit.B6 與plasma PLP有良好的相關性 (2)1993 Mascher half-life:<48 hr  反映short-term intake (3)1984 Schuster 19 adults plasma PLP and diet intake  r =0.61 • (4)1985 Willett 280 men and women by FFQ for 1yr diet intake and fasting plasma PLP r =0.37 (男) r =0.39 (女)

  3. Vitamin B6 measures • 2. 收集24-hour尿液 Vit. B6 最終代謝產物:4PA(4-pyridoxic acid) r = 0.72 • 3.erythrocyte transaminase (1)glutamate oxaloacetate transaminase (2)asparate aminotransferase 1992 Lie 265 women r=0.65 • 4.tryptophan load test 收集24-hour尿液  tryptophan metabolites

  4. Vitamin B6 • methods 1984 Sauberlich HPLC separate and quantitate different vitamin B6 • Storage • 1984 Howard plasma PLPfrozen at -20°C700 days (decline rate : 2.2% per year) • 1983 Camp plasma PLP frozen at -80°C 10 days

  5. Vitamin B6 measures • 1985 Willett Plasma PLP 與age, gender, obesity 之間的相關性甚低 10位men (20-30yrs) and 10位men (60-70yrs) plasma PLP level no difference • 1985 Leklem & 1987 Manore 劇烈運動plasma PLP and urinary Vit.B6 僅短暫的增加 • 1985 Miller 女性服用occ and 停經婦女服用estrogen均為Vit.B6缺乏之高危險群 • 1985 Bhagavan Drugs and ethanol lower plasma PLP level • 1990 Leklem Increase Protein intake and smoking  lower plasma PLP level

  6. Calcium • 1984 McCarron dietary calcium protects against hypertension • 1985 Garland dietary calcium protects against colorectal cancer • dietary calcium and osteoporosis , fracture(?) • Blood calcium level  homeostatic control

  7. Calcium • Relation between Calcium intake and urinary calcium level(?) • 1985 Castenmiller Low-Ca diet urinary calcium excretion (約為高鈣飲食的75%) Na supplementation  urinary calcium excretion  • 1988 Aalberts 22名 omnivorous , healthy male 1.12 g Ca/day(92%)  urinary calcium excretion (20%) • 1994 Joseph r = 0.05 (127 men) r = 0.16 (193 women)

More Related