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Medical Biochemistry Robert F. Waters, PhD

Medical Biochemistry Robert F. Waters, PhD. Cancer and Metabolism. ATP Structure. NAD Structure. FAD Structure. Myeloperoxidase System. Myeloperoxiase System Cont. Cu and SOD.

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Medical Biochemistry Robert F. Waters, PhD

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  1. Medical BiochemistryRobert F. Waters, PhD Cancer and Metabolism

  2. ATP Structure

  3. NAD Structure

  4. FAD Structure

  5. Myeloperoxidase System

  6. Myeloperoxiase System Cont.

  7. Cu and SOD • Two copper-transporting P-type ATPases and a novel family of proteins are termed copper chaperones, which deliver copper to specific targets within the cell. Elucidation of the structure and function of these proteins reveals a remarkable evolutionary conservation of the mechanisms of copper and iron metabolism, provides novel insights into the mechanisms of metal metabolism in the central nervous system and may allow for the development of novel therapeutic approaches to prevent or ameliorate neurodegeneration in affected patients. • Jonathan D. Gitlin, M.D. • Also: Wong PC, Waggoner D, Subramaniam J, et al. Copper chaperone for superoxide dismutase is essential to activate mammalian Cu/Zn superoxide dismutase. Proc Natl Acad Sci 2000 97:2886-2891

  8. Cancer and Myeloperoxidase • Dr. Dan Rubin • Neil Riordan, M.S., P.A. • Chan Park, M.D.

  9. Neil Riordan Paper

  10. Cancer and Vitamin C • Up to 46% have scurvy or absolute lack of Vitamin C • Test for phagocytosis • Normal in vitro levels of 40%-70% engulfing of yeast cells. • Many cancer patients 1%-2% • After Vitamin C Therapy back up to typical phagocytosis

  11. Vitamin C Cont: • Vitamin C is essential for collagen formation. • Collagen resists tumor penetration

  12. Vitamin C and Collagen Cont:

  13. Scurvy • Vitamin C deficiencies result in scurvy which affects tissues rich in collagen. Because proline and lysine residues are not hydroxylated, hydrogen bonding within triple helices and cross-linking between triple helices cannot occur. Therefore, collagen molecules are unstable characterized by bleeding gums, loose teeth, skin lesions, and weakened blood vessel walls.

  14. Vitamin C Cont: • Vitamin C induces large amounts of Hydrogen Peroxide with normal cells produce adequate catalase and cancer cells do not. • Vitamin C can kill these tumor cells and is calculated based on serum levels. • Levels may be between 25-150 grams! • More than may be ingested • Such amount ingested may cause severe diarrhea

  15. Test for G6PD prior to Vit. C Therapy • With G6PD deficiency Vitamin C therapy could destroy erythrocytes.

  16. Stress and Low Vitamin C • Production of cortisol consumes Vitamin C in the production of epinephrine.

  17. Dendritic Cell Stimulation and Anti-angiogenesis • What is dendritic cell stimulation? • Angiogenesis?

  18. Other Co-therapies • Beta 1,3 D-Glucans • Alpha Lipoic Acid reduces Vit. C requirement • Bioflavinoid Quercetin has been shown to induce tumor apoptosis • Other Vitamins!

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