'Dendritic cells' diaporamas de présentation

Immune- mediated diseases of the Nervous System. Session structure Monday 19 th – lecture Monday pm – SDL – Case: Multiple sclerosis Tuesday 20 th – Case answers. Immune- mediated diseases of the Nervous System. Aim :

Allergic Disease. Dr Garry M. Walsh, School of Medicine, University of Aberdeen. Atopy. The predisposition to produce high quantities of Immunoglobulin (Ig)-E Immediate (Type I hypersensitivity) Mast cells, basophils, eosinophils, Th2 cells. Allergy. Allergic Disease is mediated by IgE

Tolerance, autoimmunity and the pathogenesis of immune-mediated inflammatory diseases Abul K. Abbas UCSF. Balancing lymphocyte activation and control. Activation Effector T cells. Tolerance Regulatory T cells. Normal: reactions against pathogens Inflammatory

Ulcerative Colitis - before and after Hurst. D.P. Jewell University of Oxford. Samuel Wilks. The London Teaching Hospitals Experience. 300 cases Aetiology debated:-. - bacterial (Hawkins) - tinned foods / preservatives (Phillips) - psychosomatic (Claye-Shaw). Allchin 1909.

Intercalated BSc 2007-08. CELL DEATH an overview. Dr Cathy Baker 22 nd October 2007. How do cells die?. Killed by injurious agents Induced to commit suicide. NECROSIS. APOPTOSIS. LEARNING OBJECTIVES. Understand, describe and illustrate … Differences: necrosis vs. apoptosis

Become Your Own Best Editor. Three Levels of Analysis. Grammar : putting words together with punctuation as the glue Syntax : structure of larger units of discourse—phrase, sentence, paragraph, section, essay Semantics : meaning—from the level of the individual word to the discourse as a whole.

Tolerance, autoimmunity and the pathogenesis of immune-mediated inflammatory diseases Abul K. Abbas UCSF. Balancing lymphocyte activation and control. Activation Effector T cells. Tolerance Regulatory T cells. Normal: reactions against pathogens Inflammatory

Potency Measurements for Cellular and Gene Therapy Products. Denise K Gavin, Ph.D. Center for Biologics Evaluation and Research Office of Cellular, Tissue and Gene Therapies Division of Cellular and Gene Therapies denise.gavin@fda.hhs.gov.

Antigen Presentation and Dendritic Cells . Outline: 1. Review of MHC Class I and MHC Class II Presentation 2. Overview of Dendritic Cells Dendritic Cell Paradoxes Cross Presentation Problems in Cross Presentation Pathogens Exploit DCs as an Entry Route for Infection

The Integumentary System. The Skin and its Appendages. The Skin. Two main components Epidermis Dermis (Hypodermis). Epidermis. Cells of the Epidermis Keratinocytes Melanocytes Dendritic Cells (Langerhans cells). Epidermis. Layers of the Epidermis Thick Skin Stratum Basale

Lymph Node Normal Morphology. Cortex Primary Follicle Secondary Follicle Mantle Zone Paracortex Medulla Sinuses. Cortex. Primary B-Cell Follicles Nodules of small lymphocytes Lack germinal centers Secondary B-Cell Follicles Result of stimulation Germinal Centers Mantle zone.

Chapter 1: Overview of the Immune System. Innate (Non-Specific) Immunity Anatomic barriers Physiologic barriers Endocytic barriers Phagocytic barriers Inflammatory response barriers Adaptive (Specific) Immunity Properties Specificity Diversity Memory Self/non-self recognition.

ADAPTIVE IMMUNE RESPONSE. Immune response to infections 1. Innate response Neutrophils, macrophages, NK cells at site of infection 2. Initiation of adaptive response iDCs phagocytose Ag and take to nodes DCs present Ag to T cells Get specific helper (CD4) T cells

Lecture 6 Antibody genes II. Mechanism of class switching Regulation of class switching Somatic mutation T cell dependent antibody response Affinity maturation T independent antibody responses. Review session Saturday Jan 22 4:00-6:50PM YORK 2722. Next time: Mid term test.

Human Herpesvirus-8. Krystle Jones. Background. HHV-8 was discovered in 1994 by Yuan Chang and his collaborators at Columbia University. Polymerase Chain Reaction (PCR) technique allowed them to isolate 2 fragments of DNA in tissues infected with both AIDS and Kaposi’s Sarcoma.

Major Histocompatibility Complex (MHC). What is MHC? HLA H-2 Minor histocompatibility antigens. Significance of the MHC. role in immune response role in organ transplantation role in predisposition to disease. Genetic barriers to transplantation.

Cytokines. Functions Receptors Signaling Chapter 11. Cytokines are soluble mediators (small proteins) of innate and adaptive immunity and the mechanisms by which leukocytes communicate with one another. Functions of cytokines. stimulation inhibition differentiation cell death

Major Histocompatibility Complex, aka MHC. “ A complex of genes encoding cell-surface molecules that are required for antigen presentation to T-cells … ” Fundamentally important: basis of self / not self distinction presentation of processed antigen

Leukopenia, leukocytosis. Follicular hyperplasia. NEOPLASTIC PROLIFERATIONS OF WHITE CELLS. Lymphoid neoplasms The phenotype of the tumor cells resembles that of normal counterparts Myeloid neoplasms Origin of hematopoietic stem cells that give rise to cells of the myeloid lineage

Chapter 11 Antigen Processing and Presentation. B. B. B. B. B. B. B. B. B. Y. Y. Y. Y. Y. Y. Y. Y. Y. Y. T. T. Y. Y. T cells do not recognise native antigens. Y. Y. Y. Y. Y. Y. Cross-linking of surface membrane Ig. Proliferation and antibody production.