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CHAPTER 1 BLOOD AND MARROW TRANSPLANTATION

CHAPTER 1 BLOOD AND MARROW TRANSPLANTATION. Editors : Dr Alan Teh Kee Hean Prof Dr Chan Lee Lee Expert Panel: Dr Alan Teh Kee Hean (co-chairperson) Prof Dr Chan Lee Lee (co-chairperson) Prof Dr Gan Gin Gin Dr Hishamshah Mohd Ibrahim Prof Dr S. Fadilah Abdul Wahid Dr Ong Tee Chuan.

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CHAPTER 1 BLOOD AND MARROW TRANSPLANTATION

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  1. CHAPTER 1BLOOD AND MARROW TRANSPLANTATION Editors: Dr Alan Teh Kee Hean Prof Dr Chan Lee Lee Expert Panel: Dr Alan Teh Kee Hean (co-chairperson) Prof Dr Chan Lee Lee (co-chairperson) Prof Dr Gan Gin Gin Dr Hishamshah Mohd Ibrahim Prof Dr S. Fadilah Abdul Wahid Dr Ong Tee Chuan

  2. New patients Alive at 31st Dec 1,000 800 600 Number of patients (n) 400 200 0 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 Year Table 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2008 Figure 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2008

  3. 7 6 5 4 New Tranplant rate pmp 3 2 1 0 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 Year Table 1.1.2: New Transplant Rate per million population (pmp), 1987-2008 Figure 1.1.2: New Transplant Rate per million population (pmp), 1987-2008

  4. Table 1.1.3: Distribution of Patients by Transplant Centre, 1987-2008

  5. Table 1.1.3: Distribution of Patients by Transplant Centre, 1987-2008

  6. KLA GMC KLP LWE UKM SJA SJP UMA HUSM UMP ASH HA HPP Others 140 100 120 90 80 100 70 80 60 Number of patients (n) Number of patients (n) 50 60 40 40 30 20 20 10 0 0 87 87 88 88 89 89 90 90 91 91 92 92 93 93 94 94 95 95 96 96 97 97 98 98 99 99 00 00 01 01 02 02 03 03 04 04 05 05 06 06 07 07 08 08 Year Year Figure 1.1.3: Distribution of Patients by Centre, 1987-2008

  7. Male Female 100 90 80 70 60 Percentage of patients (%) 50 40 30 20 10 0 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 Year Table 1.2.1: Distribution of Patients by Gender, 1987-2008 Figure 1.2.1: Distribution of Patients by Gender, 1987-2008

  8. Table 1.2.2: Distribution of Patients by Ethnic Group, 1987-2008

  9. Malay Chinese Indian Bumiputera Sabah Bumiputera Sarawak Others 100 90 80 70 60 Percentage of patients (%) 50 40 30 20 10 0 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 Year Figure 1.2.2: Distribution of Patients by Ethnic Group, 1987-2008

  10. Table 1.2.3: Distribution of Patients by Age Group, 1987-2008

  11. 0-9 years 10-19 years 20-39 years 40-59 years ≥60 years 100 90 80 70 60 Percentage of patients (%) 50 40 30 20 10 0 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 Year Figure 1.2.3: Distribution of Patients by Age Group, 1987-2008

  12. Table 1.2.4: Distribution of Patients by Primary Diagnosis, 1987-2008

  13. Table 1.3.1: Distribution of Patients by Graft Number, 1987-2008 • Note: Missing in graft number = 71 patients (5%)

  14. Graft number 1 Graft number 2 Graft number 3 100 80 60 Percentage of patients (%) 40 20 0 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 Year Figure 1.3.1: Distribution of Patients by Graft Number, 1987-2008

  15. Table 1.3.2: Distribution of Patients by Transplantation Type, 1987-2008

  16. Allogeneic+Syngeneic Autologous 180 160 140 120 100 Number of patients (n) 80 60 40 20 0 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 Year Figure 1.3.2: Distribution of Patients by Transplantation Type, 1987-2008

  17. Allogeneic+Syngeneic Autologous 300 250 200 Number of patients (n) 150 100 50 0 KLA KLP UKM SJA UMA UMP GMC LWE SJP HUSM ASH HA HPP Other Centre Table 1.3.3: Type of Transplant by Centre, 1987-2008 Figure 1.3.3: Type of Transplant by Centre, 1987-2008

  18. Table 1.3.4: Source of Stem Cells, 1987-2008

  19. Marrow PBSC/ Marrow+ PBSC Cord blood/ Marrow + cord 180 160 140 120 100 Number of patients (n) 80 60 40 20 0 87 88 89 90 91 92 93 94 95 96 97 98 99 00 01 02 03 04 05 06 07 08 Year Figure 1.3.4: Source of Stem Cells, 1987-2008

  20. Table 1.3.5: Distribution of Patients by HLA Match, 1987-2008

  21. Table 1.3.6: Distribution of Patients by Allogeneic Donor Relationship, 1987-2008

  22. Table 1.4.1: Distribution of Patients by Cause of Death, 1987-2008

  23. Table 1.4.1: Distribution of Patients by Cause of Death, 1987-2008

  24. Figure 1.4.1: Patient Survival by Year of Transplant, 1987-2008 Figure 1.4.2: Patient Survival by Gender, 1987-2008

  25. 1.00 0.75 0.50 Cumulative survival 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years 0-9 years 10-19 years 20-39 years ≥40 years Figure 1.4.3: Patient Survival by Age Group, 1987-2008 Figure 1.4.4: Patient Survival by Type of Transplant, 1987-2008

  26. Figure 1.5.1: Disease-free Survival for Acute Myeloid Leukaemia, 1987-2008 (Allogeneic vs. Autologous)

  27. Figure 1.5.2: Disease-free Survival for Acute Lymphoblastic Leukaemia, 1987-2008 (Allogeneic)

  28. Figure 1.5.3: Disease-free Survival for Thalassaemia, 1987-2008 (Allogeneic)

  29. Figure 1.5.4: Disease-free Survival for Non-Hodgkin’s Lymphoma, 1987-2008 (Allogeneic vs. Autologous)

  30. Figure 1.5.5: Disease-free Survival for Hodgkin’s Disease, 1987-2008 (Autologous)

  31. Figure 1.5.6: Disease-free Survival for Chronic Myeloid Leukaemia, 1987-2008 (Allogeneic)

  32. Figure 1.5.7: Disease-free Survival for AplasticAnaemia, 1987-2008 (Allogeneic)

  33. Figure 1.5.8: Disease-free Survival by Age Group for Acute Myeloid Leukaemia, 1987-2008 • Pediatric is defined as age 18 years and adult age >18 years .

  34. Figure 1.5.9: Disease-free Survival by Age Group for Acute Lymphoblastic Leukaemia, 1987-2008 • Pediatric is defined as age 18 years and adult age >18 years .

  35. Figure 1.5.10: Disease-free Survival by Age Group for Thalassaemia, 1987-2008

  36. Figure 1.5.11: Disease-free Survival by Age Group for Non-Hodgkin’s Lymphoma, 1987-2008 • Pediatric is defined as age 18 years and adult age >18 years .

  37. Figure 1.5.12: Disease-free Survival by Age Group for Hodgkin’s Disease, 1987-2008 • Pediatric is defined as age 18 years and adult age >18 years .

  38. Figure 1.5.13: Disease-free Survival by Age Group for Chronic Myeloid Leukaemia, 1987-2008

  39. Figure 1.5.14: Disease-free Survival by Age Group for AplasticAnaemia, 1987-2008 • Pediatric is defined as age 18 years and adult age >18 years .

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