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Table 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2006

Table 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2006. *1 patient in year transplant 2001 with no death date *Out of 1174 patients who were transplanted, there were 49 patients with early death before day 30 of transplant. New patients. Alive at 31st Dec. 800. 700.

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Table 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2006

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  1. Table 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2006 *1 patient in year transplant 2001 with no death date *Out of 1174 patients who were transplanted, there were 49 patients with early death before day 30 of transplant

  2. New patients Alive at 31st Dec 800 700 600 500 Number of patients (n) 400 300 200 100 0 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 Year Figure 1.1.1: Stock and Flow of Blood and Marrow Transplantation, 1987-2006

  3. Table 1.1.2: New Transplant Rate per million population (pmp), 1987-2006

  4. 6 5 4 New transplant rate pmp 3 2 1 0 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 Year Figure 1.1.2: New Transplant Rate per million population (pmp), 1987-2006

  5. Table 1.1.3: Distribution of Patients by Centre, 1987-2006

  6. Table 1.1.3: Distribution of Patients by Centre, 1987-2006 Note: Distribution is according to transplant centre *Others include Royal Perth Hospital

  7. KLA KLP UKM SJA UMA KLP UMA UMP 150 140 130 120 110 100 90 80 Number of patients (n) 70 60 50 40 30 20 10 0 1993 1987 1989 1991 1995 1997 1999 2001 2003 2005 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 Year Figure 1.1.3: Distribution of Patients by Centre, 1987-2006

  8. SJP LWE GMC others Hospital Ampang ASH 150 140 130 120 110 100 90 80 70 Number of patients (n) 60 50 40 30 20 10 0 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 1988 1990 1992 1994 1996 1998 2000 2002 2004 2006 Year Figure 1.1.3: Distribution of Patients by Centre, 1987-2006

  9. Table 1.2.1: Distribution of Patients by Gender, 1987-2006

  10. Male Female 100 80 60 Percentage of patients (%) 40 20 0 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 Year Figure 1.2.1: Distribution of Patients by Gender, 1987-2006

  11. Table 1.2.2: Distribution of Patients by Ethnic Group, 1987-2006

  12. Figure 1.2.2: Distribution of Patients by Ethnic Group, 1987-2006 Malay Chinese Indian Bumiputra Sabah Bumiputra Sarawak Others 100 90 80 70 Percentage of patients (%) 60 50 40 30 20 10 0 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 Year

  13. Table 1.2.3: Distribution of Patients by Age Group, 1987-2006

  14. Table 1.2.3: Distribution of Patients by Age Group, 1987-2006 *Age=date of transplant – date of birth

  15. 0-9 years 10-19 years 20-39 years 40-59 years ≥60 years 100 90 80 70 Percentage of patients (%) 60 50 40 30 20 10 0 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 Year Figure 1.2.3: Distribution of Patients by Age Group, 1987-2006

  16. Table 1.2.4: Distribution of Patients by Primary Diagnosis, 1987-2006

  17. Table 1.2.4: Distribution of Patients by Primary Diagnosis, 1987-2006

  18. Table 1.3.1: Distribution of Patients by Graft Number, 1987-2006

  19. Graft number 1 Graft number 2 Graft number 3 100 80 Percentage of patients (%) 60 40 20 0 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 Year Figure 1.3.1: Distribution of Patients by Graft Number, 1987-2006

  20. Table 1.3.2: Distribution of Patients by Transplantation Type, 1987-2006 Note: 6 patients with syngeneic type of transplant

  21. Allogeneic + Syngeneic Autologous 140 120 100 Number of patients (n) 80 60 40 20 0 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 Year Figure 1.3.2: Distribution of Patients by Transplantation Type, 1987-2006

  22. Table 1.3.3: Type of transplant by Centre, 1987-2006 * Others include Royal Perth Hospital

  23. Allogeneic + Syngeneic Autologous 280 260 240 220 200 180 160 140 Number of patients (n) 120 100 80 60 40 20 0 KLA UKM UMA GMC SJP Ampang KLP SJA UMP LWE ASH Others Centre Figure 1.3.3: Type of transplant by Centre, 1987-2006

  24. Table 1.3.4: Source of Transplant, 1987-2006 PBSC = Peripheral Blood Stem Cells

  25. Marrow PBSC / Marrow+ PBSC Cord blood/ Marrow + cord 140 120 100 80 Number of patients (n) 60 40 20 0 1987 1989 1991 1993 1995 1997 1999 2001 2003 2005 Year Figure 1.3.4: Source of Transplant, 1987-2006

  26. Table 1.3.5: Distribution of Patients by HLA Match, 1987-2006 *excluding autologous

  27. Table 1.3.6: Distribution of Patients by Allogeneic Donor Relationship, 1987-2006

  28. Table 1.3.6: Distribution of Patients by Allogeneic Donor Relationship, 1987-2006 *excluding autologous, including syngeneic

  29. Table 1.4.1: Distribution of Patients by Cause of Death, 1987-2006

  30. Table 1.4.1: Distribution of Patients by Cause of Death, 1987-2006 Note: 1 patient with missing cause of death reported

  31. 1.00 0.75 0.50 Cumulative survival 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Year 1987-1992 Year 1993-1998 Year 1999-2006 Figure 1.4.1: Patient Survival by Year of Transplant, 1987-2006

  32. 1.00 0.75 0.50 Cumulative survival 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Male Female Figure 1.4.2: Patient Survival by Gender, 1987-2006

  33. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years 0-9 years 10-19 years 20-39 years ≥40 years Figure 1.4.3: Patient Survival by Age Group, 1987-2006

  34. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Allogeneic + Syngeneic Autologous Figure 1.4.4: Patient Survival by Type of Transplant, 1987-2006

  35. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Allogeneic Autologous Figure 1.5.1: Disease-free Survival for Acute Myeloid Leukaemia, 1987-2006 (Allogeneic vs. Autologous)

  36. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Allogeneic Figure 1.5.2: Disease-free Survival for Acute Lymphoblastic Leukaemia,1987-2006 (Allogeneic)

  37. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Allogeneic Figure 1.5.3: Disease-free Survival for Thalassaemia, 1987-2006 (Allogeneic)

  38. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Allogeneic Autologous Figure 1.5.4: Disease-free Survival for Non-Hodgkin’s Lymphoma, 1987-2006 (Allogeneic vs. Autologous)

  39. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Autologous Figure 1.5.5: Disease-free Survival for Hodgkin’s Disease, 1987-2006 (Autologous)

  40. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Allogeneic Figure 1.5.6: Disease-free Survival for Chronic Myeloid Leukaemia, 1987-2006(Allogeneic)

  41. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Allogeneic Figure 1.5.7: Disease-free Survival for Aplastic Anaemia, 1987-2006 (Allogeneic)

  42. 1.00 0.75 0.50 Cumulative survival 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Paediatric Adult Figure 1.5.8: Disease-free Survival by Age Group for Acute Myeloid Leukaemia,1987-2006 Paediatric is defined as age 18 years and adult age >18 years

  43. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Paediatric Adult Figure 1.5.9: Disease-free Survival by Age Group for Acute Lymphoblastic Leukaemia,1987-2006 Paediatric is defined as age 18 years and adult age >18 years

  44. 1.00 0.75 0.50 Cumulative survival 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Paediatric Figure 1.5.10: Disease-free Survival by Age Group for Thalassaemia, 1987-2006 * No adult cases reported for Thalassaemia Paediatric is defined as age 18 years and adult age >18 years

  45. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Paediatric Adult Figure 1.5.11: Disease-free Survival by Age Group for Non-Hodgkin’s Lymphoma,1987-2006 Paediatric is defined as age 18 years and adult age >18 years

  46. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Paediatric Adult Figure 1.5.12: Disease-free Survival by Age Group for Hodgkin’s Disease,1987-2006 Paediatric is defined as age 18 years and adult age >18 years

  47. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Paediatric Adult Figure 1.5.13: Disease-free Survival by Age Group for Chronic Myeloid Leukaemia,1987-2006 Paediatric is defined as age 18 years and adult age >18 years

  48. 1.00 0.75 Cumulative survival 0.50 0.25 0.00 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 Duration in years Paediatric Adult Figure 1.5.14: Disease-free Survival by Age Group for Aplastic Anaemia,1987-2006 Paediatric is defined as age 18 years and adult age >18 years

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