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Transplantation

0. Transplantation. Rejection of foreign tissue grafts is due to immune responses to alloantigens on the graft Blood group antigens Polymorphic MHC antigens Minor histocompatibility antigens. 0. B. Menu. F. 0. B. Menu. F. 0. Alloantigen Presentation. Direct recognition

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Transplantation

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  1. 0 Transplantation • Rejection of foreign tissue grafts is due to immune responses to alloantigens on the graft • Blood group antigens • Polymorphic MHC antigens • Minor histocompatibility antigens

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  4. 0 Alloantigen Presentation • Direct recognition • MHC-peptide complexes on Donor APC are recognized directly by recipient T cells without processing by recipient APC • Indirect recognition • Foreign MHC and other alloantigens are processed by recipient APC and presented to recipient T cells

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  7. 0 Transplantation • Rejection is mediated primarily by T cells but antibodies are also important • Rejection occurs with the same timing as other immune responses • Hyperacute rejection • Acute Rejection: First-set rejection &Second set rejection • Chronic rejection

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  11. 0 Graft vs. Host disease • When immunocompetent T cells are transplanted into a tissue incompatible immunodeficient recipient the donor T cells recognize and reject the recipient • This is more of a problem in bone marrow transplantation but can occur in any grafting procedure

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