1 / 9

Examination of Myosin-V and Scallop Muscle Conformations in the Pre-Power Stroke State

This study explores the structural dynamics of myosin-V and scallop muscle conformations during the pre-power stroke state using PDB entries 1BR1, 1QVI, and 1W7I. By employing docking techniques via SITUS, we analyze the interactions of ADP-bound myosin-V with F-actin, focusing on conformational states that exhibit outward and inward movements. The correlation coefficients (CC) indicate varying degrees of fitting and flexibility across conformations, highlighting the differences between smooth muscle-like and scallop-like structures during myosin ATPase activity.

manton
Télécharger la présentation

Examination of Myosin-V and Scallop Muscle Conformations in the Pre-Power Stroke State

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Segmentation outward inward

  2. Three Conformations pre-power stroke state in smooth muscle (PDB - 1BR1) pre-power stroke state in scallop muscle (PDB - 1QVI) Myosin-V with ADP (PDB -1W7I) F-actin

  3. CC= 0.64 CC= 0.58 CC= 0.53 CC= 0.41 CC= 0.42 CC= 0.42 Docking by SITUS (colores) outward inward ADP myosin-V Scallop-like pre-power stroke smooth muscle-like pre-power stroke

  4. CC= 0.64 CC= 0.58 CC= 0.53 CC= 0.41 CC= 0.42 CC= 0.42 Docking by SITUS (colores) outward inward ADP myosin-V Scallop-like pre-power stroke smooth muscle-like pre-power stroke

  5. Docking by SITUS (myoV-ADP) outward CC= 0.64 ADP myosin-V

  6. Normal Mode Flexible Fitting (myoV-ADP) outward CC= 0.82 ADP myosin-V

  7. Docking by SITUS (scallop-like) outward CC= 0.58 Scallop-like pre-power stroke

  8. Normal Mode Flexible Fitting (scallop-like) outward CC= 0.77 Scallop-like pre-power stroke

  9. Fitted “scallop-like” on F-actin pre-power stroke statein smooth muscle myosin (PDB - 1BR1) pre-power stroke statein scallop myosin (PDB -1QVI) Myosin-V with ADP (PDB -1W7I) F-actin F-actin

More Related