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Social breeding made AD-prone mice smarter

Environmental Effect on Behavior. Social breeding made AD-prone mice smarter. Martins, et al., The EMBO Journal (2008) 27, 224–233, Lipids revert inert A β amyloid fibrils to neurotoxic protofibrils that affect learning in mice. Speaker: Cheng-Yu Li 2009/10/02. Background.

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Social breeding made AD-prone mice smarter

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  1. EnvironmentalEffect on Behavior Social breeding made AD-prone mice smarter Martins, et al., The EMBO Journal (2008) 27, 224–233, Lipids revert inert Aβamyloid fibrils to neurotoxic protofibrilsthat affect learning in mice Speaker: Cheng-Yu Li 2009/10/02

  2. Background • AD-prone Mice • Act like Alzheimer’s patient • Weak of learning ability • Social breeding vs. Isolated breeding

  3. Light–dark step through task (passive avoidance test) • The group of Isolated-breeding mice have worse ability about memory formation. • Social-breeding treatment can improve AD-prone mice’s memory ability.

  4. Conditioned fear response • Social-breeding mice performed better than isolated-breeding mice in conditioned fear response.

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