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Hepatobiliary System Histology: A Comprehensive Guide

Learn the intricacies of hepatobiliary histology, including liver lobule structure, hepatic acinus zones, portal triad components, Kupffer cells, blood and bile flow pathways, gallbladder layers, and more.

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Hepatobiliary System Histology: A Comprehensive Guide

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  1. Histology for PathologyHepatobiliary System(Accessory Digestive Organs) Silver Daniel, MD Assistant Professor Theresa Kristopaitis, MD Associate Professor Director of Mechanisms of Human Disease Kelli A. Hutchens, MD, FCAP Assistant Professor Assistant Director of Mechanisms of Human Disease Loyola Stritch School of Medicine

  2. Hepatobiliary Histology • On a low power H&E stained section outline a liver lobule. • Explain the rationale of dividing the hepatic acinus into three zones. • Identify the components of the portal triad/tract: portal vein, hepatic artery, bile duct. • Identify hepatic sinusoids and describe the endothelium that lines the sinusoids. • Define “Kupffer cells” and their function. • List the structures that form the space of Disse. • Describe the path of blood flow as it is filtered through the liver. • Describe the location of bile canaliculi and their function. • Describe the path of bile flow from the liver to the gallbladder. • Identify the three layers of the gallbladder: mucosa, muscularis and serosa/adventitia.

  3. Image courtesy of Robbins and Cotran Pathologic Basis of Disease, 7th edition

  4. Image courtesy of www.apsu.edu

  5. Image courtesy of Nature Reviews Immunology , March 2006

  6. Biliary TractFlow of bile from liver

  7. Image courtesy of Robbins and Cotran Pathologic Basis of Disease, 7th edition

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