Reticular fibers

4. Reticular fibers

19. Overview Cytotoxic T cells B Cells Antigen Presenting Cells Helper T cells Activate Help Activate Help Activate Cell mediateted immunity antibody mediateted immunity

28. Figure 2. Activation of naive T-cells requires two independent signals. The binding of the peptide:MHC complex by the T-cell receptor and, in this example, the CD4 co-receptor transmits a signal (signal 1 indicated by arrow 1) to the T-cell that antigen has been recognized. Activation of naive T-cells requires a second signal (signal 2 indicated by arrow), the co-stimulatory signal, which is delivered by the same antigen-presenting cell (APC). From Janeway CA, Jr., and Travers P. Immunobiology. 2nd edition, 1996, pp. 7:8, with permission from the publisher, Current Biology, Ltd, London.

33. Figure 1-14: Cellular Interactions Cellular interactions involved in induction of immune responses. Activation and proliferation of TH cells. (a) is required for generation of humoral response (b) and cell-mediated response to altered self-cells (c). APC = antigen-presenting cell; Ag = antigen.

34. Helpful animations http://highered.mcgraw-hill.com/sites/0072507470/student_view0/chapter22/animation__t-cell_dependent_antigens__quiz_2_.html http://highered.mcgraw-hill.com/sites/0072507470/student_view0/chapter22/animation__cytotoxic_t-cell_activity_against_target_cells__quiz_2_.html

35. Helper T cells 1 & Helper T cells 2