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Thyroid Stimulating Hormone

Thyroid Stimulating Hormone. By: Cooper Nichols. Where it comes from and affects. Thyroid Stimulating Hormone (TSH) is produced in the pituitary gland. After being produced and released from the pituitary gland, its target is the thyroid gland where it tests for any problems in the thyroid.

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Thyroid Stimulating Hormone

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  1. Thyroid Stimulating Hormone By: Cooper Nichols

  2. Where it comes from and affects • Thyroid Stimulating Hormone (TSH) is produced in the pituitary gland. • After being produced and released from the pituitary gland, its target is the thyroid gland where it tests for any problems in the thyroid. • TSH is produced after the hypothalamus releases Thyrotropin-Releasing Hormone (TrH) to inform the pituitary to make TSH to check for thyroid issues.

  3. Structure of TSH: Protein (201)

  4. How TSH enters the thyroid • Because TSH is a protein and not a steroid, it cannot pass directly through the plasma membrane. • In order to get into the thyroid, TSH attaches to receptor cells that then allow it to enter in and do its job.

  5. Facts about tsh • Up until the age of three, TSH is most active in people in order for normal growth. • Normal levels of TSH in the blood are shown in the table below. • After TSH is released and it enters the thyroid, it causes the thyroid to release Triiodothyronine (T3) and Thyroxine(T4) that account for normal growth.

  6. Disorders associated with TSH • Goiter- an enlargement of the thyroid gland. It is not cancer. • Graves’ Disease- an autoimmune disorder that leads to overactivity of the thyroid gland (hyperthyroidism). • Hashimoto’s Thyroiditis- swelling (inflammation) of the thyroid gland that often results in reduced thyroid function (hypothyroidism). • Iodine Deficiency- causes abnormal function of the thyroid

  7. Goiter/Iodine Deficiency Graves’ Disease Hashimoto’s Thyroiditis

  8. Treating TSH diseases • In order to treat people that have either overactive or underactive thyroids, people must either get their thyroid removed and take replacement supplements or work to lower their iodine counts (for overactive), or take iodine pills to get their count up (for underactive.

  9. Thyroid Stimulating Hormone Replacement • If your thyroid has to be removed because of complications, you must go through thyroid hormone replacement therapy and take levothyroxine for the rest of your life for your body to function properly.

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