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Toxicity testing on animals

Toxicity testing on animals. No Observed Effect Level (NOEL) = Exposure with no adverse effects in animal models. ÷ 10. NOEL for human exposure. Data from case reports and observational studies. Risk assessment -Which adverse effect seen in animals are likely to also affect human health?

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Toxicity testing on animals

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  1. Toxicity testing on animals No Observed Effect Level (NOEL) = Exposure with no adverse effects in animal models ÷ 10 NOEL for human exposure Data from case reports and observational studies Risk assessment -Which adverse effect seen in animals are likely to also affect human health? -What dose is required to observe adverse effects? - What exposures are likely in different user groups (such as manufacturers or consumers)? Final Risk Assessment ÷ 10 Safe exposure limit

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