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DEEP / SYSTEMIC MYCOSES

DEEP / SYSTEMIC MYCOSES. Dr. A.Aziz Djamal MSc.DTM&H.SpMK(K ). There are two types :. Cosmopolitant : Aspergillus, Candida and Cryptococcosis. 2. Exotic type : In a specific area Penicillium marneffei.

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DEEP / SYSTEMIC MYCOSES

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  1. DEEP / SYSTEMIC MYCOSES Dr. A.Aziz Djamal MSc.DTM&H.SpMK(K)

  2. There are two types : Cosmopolitant : Aspergillus, Candida and Cryptococcosis. 2. Exotic type : In a specific area Penicillium marneffei

  3. Deep / Systemic Mycoses A Group of Fungi that cause a variety of systemic / deep seated infection each ranging in severity from subclinical to progressive , debilitating diseases

  4. Several Deep Mycoses : Aspergillus. Candida Cryptococcus Penicillicium marneffei. Coccidioides. Paracoccidioides. Mucormycoses. Paehypomycoses Blastomycoses. Pseudallescheriasis. Fusariosis

  5. Aspergillus Common species : Aspergillus fumigatus Aspergillus flavus

  6. Aspergillus Characteristic Typically asexual sporulationSeptatehyphaePalliadesVesicleMicroconidia

  7. Aspergillus systemic diseases Sinusitis : Unilateral,non-invasive, maxillary sinus. Pulmonary aspergilloma : Free and mobile Fungus ball in residual lung cavity/tb ,interwoven hyphae, haemoptysis. Invasive Pulmonary aspergillosis : With or Without Deep Lesion. Fatal opportunistic infection in certain group of netrophenia, extrapulmonary. AIDS.

  8. Diagnoses : 1.Sinusitus aspergillus : Direct examination or histological biopsy examination. 2. Pulmonary aspergilloma : Sputum culture. Precipitin specific to A. fumigatus or A. flavus 3. Invasive Pulmonary Aspergillosis : Clinical outcome, Immune status and fungus isolation.

  9. Systemic Candidiasis Only on Predisposed patient / Opportunistic. Local or systemic predisposing factors. Persoption not exogenous infection.

  10. Clinical Manifestation : Oesophagitis colitis Pulmonary candidosis ( haematagenous or direct contact) Kidney Eye Chronic : Liver and Spleen Abscesin leukemia Meningitis in premature baby.Endocarditis in heart surgery / valve prothesis

  11. Cryptococcoses Causative Agent :Cryptococcus neoformans var. neoformans ( cosmopolitant) var gattii ( Exclusive in tropic )

  12. Cryptococcus neoformans Yeast : 4-6 micrometer characteristic capsule ext ; 25 micrometer. capsule : complex polysaccharide polymer Glucoronoxylomannan ( GXM)

  13. Mostly in Impaired immunity patient:20-25 % of AIDS patients in South east Asia.Mostly varneoformans 99 %Aerial transmission-lung-meningitis

  14. Others : HistoplasmacapsulatumBlastomycesdermatitidis and Coccidioidesimmitis

  15. Candida cause systemic infection :1. C. albicans.2. C. parapsilosis.3. C. tropicalis.4. C. krusei.5. C. gulliermondii.6. C. kefyr.7. C. lusitaniae8. C. zeylanoides.9. C. glabrata.

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