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Po-Chang Lee, M.D.,M.T.L. Professor of Surgery National Cheng Kung University Hospital, Taiwan

Terasaki Festschrift 2014 Clinical Relevance of Pre- and Post-Transplant HLA antibodies, Donor-Specific and Non-Donor-Specific HLA Antibodies Detected by ELISA in Renal Transplantation. Po-Chang Lee, M.D.,M.T.L. Professor of Surgery National Cheng Kung University Hospital, Taiwan

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Po-Chang Lee, M.D.,M.T.L. Professor of Surgery National Cheng Kung University Hospital, Taiwan

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  1. Terasaki Festschrift 2014Clinical Relevance of Pre- and Post-Transplant HLA antibodies, Donor-Specific and Non-Donor-Specific HLA Antibodies Detected by ELISA in Renal Transplantation Po-Chang Lee, M.D.,M.T.L. Professor of Surgery National Cheng Kung University Hospital, Taiwan Chairperson of the Board Taiwan Organ Registry and Sharing Center

  2. 0 <6M 1yr 2 3 4 5 6 7 8yr De novo Post-Transplant Antibody Lee PC, Terasaki PI, et al.Transplantation 2002; 74(8): 1192-1194

  3. 2. Dangerous Late Failure Early Lee, PC, Terasaki, et al, Early antibodies Transplantation 2009;88:568-574

  4. HLA Abs detected method and cost • ELISA • LATM (Screening): US12 • LAT (Identification): US60 • Luminex • LAB (single antigen bead assay): US 558

  5. Table 1. Patient characteristics

  6. Figure 1. Pre- Transplant HLA Antibodies being Detected

  7. Table 2. Comparison of Graft Survival According to Pre-transplant HLA Antibodies, DSA and NDSA being Detected

  8. Figure 2. Post-transplant HLA Antibodies being Detected

  9. Table 3. Comparison of Graft Survival According to Post-transplant HLA Antibodies, DSA and NDSA being Detected

  10. Figure 3. Post-transplant HLA Antibodies to Class I or Class II being Detected

  11. Table 4. Comparison of Graft Survival According to Pre-transplant and Post-transplant HLA Antibodies being Detected

  12. Figure 4. Comparison of Graft Survival According to Pre- transplant CDC-XM and DTT CDC-XM

  13. Take Home Message There was a significant difference in graft survival between patients with pre-transplant NDSA and those without HLA antibodies (P=0.0005) . 2. There was a significant difference in graft survival between patients with post-transplant DSA and those without HLA antibodies (P=0.006) . 3. For patients who had persistent pre- and post-transplant HLA antibodies, worst long term survival could be found. 4, We believe HLA antibody analysis by ELISA is still very useful for transplantation.

  14. National Cheng Kung University Hospital, Tainan, Taiwan

  15. Q & A

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