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Advanced AAV Vector Constructs: Replication and Capsid Variants Analysis

This document explores a series of adeno-associated virus (AAV) vector constructs characterized by various replication conditions and capsid protein modifications. Emphasizing constructs such as AAV2 ITR and Rep/Cap elements, we discuss their potential for gene delivery applications. The analysis includes multiple constructs featuring altered translation initiation sites (ΔATG) and alternative capsid configurations. This research will enhance understanding of how these modifications impact transduction efficiency and therapeutic potential in gene therapy programs.

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Advanced AAV Vector Constructs: Replication and Capsid Variants Analysis

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  1. 191 p5 310 ATG p19 p40 A: AAV2 ITR Rep Cap ITR BamH I 310 ATG p19 p40 B: pAAV-RC Rep Cap 813 bp BamH I BamH I 310 ΔATG p19 p40 C: pAAV-RC/ΔATG Rep Cap 810 bp BamH I BamH I 310 ACG p19 p40 D: pAAV-RC/ACG Rep Cap 813 bp BamH I BamH I ACG p19 ACG p19 p40 E: pAAV-RC/p19/ACG Rep Cap 813 bp 813 bp BamH I BamH I BamH I 191 p5 310 ATG p19 p40 F: pAAV-RC/p5 Rep Cap 866 bp BamH I BamH I 191 p5 310 ACG p19 p40 G: pAAV-RC/p5/ACG Rep Cap 866 bp BamH I BamH I

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