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Company profile

Company profile. Where you can find us. y our partner in sophisticated o rganic c hemistry. VUOS ownership. AGROFERT HOLDING,a.s. 100%. SYNTESIA, a.s. 100%. VÝZKUMNÝ ÚSTAV ORGANICKÝCH SYNTÉZ a.s. (VUOS. y our partner in sophisticated o rganic c hemistry. 1941. 1952. 1992. 1997.

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Company profile

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  1. Company profile

  2. Where you can find us your partner in sophisticated organic chemistry

  3. VUOS ownership AGROFERT HOLDING,a.s.. 100% SYNTESIA, a.s. 100% VÝZKUMNÝ ÚSTAV ORGANICKÝCH SYNTÉZ a.s. (VUOS your partner in sophisticated organic chemistry

  4. 1941 1952 1992 1997 2004 2009 History Foundation of Research Laboratories Affiliation of Synthesia´s R&D 100% daughter company of Synthesia a.s. New name – VUOS Voucher Privatisation • prepared for the sale

  5. VUOS main businesses • R&D andProductionof Fine chemicals • Toxicologyandanalytics Emloyees in % Sales in % your partner in sofisticated organic chemistry

  6. The Certificates of VUOS • ISO 9001:2001 • Certificate of Good Laboratory Practice • Certificate of Accreditation for Certification of Products No. 229/2002 • Certificate of Accreditation No. 230/2002 Testing Laboratory No. 1057 • Certificate on Compliance with Principles of Good Laboratory Practice • Certificate on Compliance with Principles of Good Manufacturing Practice in laboratory your partner in sofisticated organic chemistry

  7. Strong Points • Education structure of employees • VUOS is located in area of long-lasting. chemical tradition with complete infrastructure • Cooperation with University of Pardubice your partner in sofisticated organic chemistry

  8. Research &Development • pharmaceutical intermediates • intermediates for microelectronics • custom syntheses of chemical specialities • dyes and pigments for special application your partner in sofisticated organic chemistry

  9. Fine Chemicals Production Wide range of quantities Grams– in laboratory Kilograms– in kilolab unit Metric tons – in production plant Hundreds of MT – in Synthesia your partner in Fine Chemicals

  10. VUOS's technology / manufacture expertise include: Key know-howand technologies: • Adamantanes • N-heterocycles • Halogen an sulfur derivatives • Building Blocks • Key chemistry • Catalytic hydrogenation • Phosgenation your partner in Fine Chemicals

  11. C O O H VUOS's technology / manufacture expertise include: dehydrohalogenation diazotisation elimination esterification Friedel-Crafts reaction heterocyclic synthesis hydrolysis reactions neutralisation nitration nitriles syntheses oxidation – catalytic/chemical oxidation in liquid phase rearrangement reduction with hydrazine and sodium borohydride sulfonation • acetylation • aldolisation • amidation • alkylation • amination • amoxidation • alkali fusion • arylhydrazines syntheses • azocoupling • benzoylation • chiral synthesis • chlorination • chlorosulfonation • cyclisation • Claisen condensation • decarboxylation your partner in Fine Chemicals

  12. Kilolab Unit 2x reactors, 250 and 650 l 2x High performance rectification columns Phosgenation your partner in Fine Chemicals

  13. Kilolab Unit 3x autoclaves 100 l each, 60, 120 and 130 bar, up to 200˚C, Hastelloy C clad 1x autoclave 300 l, 120 bar, 140˚C, Hastelloy C clad 1x autoclave 700 l, 100 bar, 200oC, stainless steel 1x autoclave 1,000 l, 10 bar, 140˚C, stainless steel many autoclaves up to 10 l Hydrogenation your partner in Fine Chemicals

  14. Kilolab Unit 1 x glass reactor 50 l cooled down to – 80˚C 1x glasslined reactor for NaH reactions (250 l) 3x glass reactors 100l for RLi, Grignard reactions Low temperature, RLi, RMgX, NaH your partner in Fine Chemicals

  15. Kilolab Unit 20x glass reactors, 100 l each 6x glass lined reactors (200 – 1,500 l) 2x evaporators 50 l / h 4x stainless steel reactors (300 – 1,500 l) sufficient filtration and distillation capacity Multipurpose chemistry your partner in Fine Chemicals

  16. Production Plant Equipment 45x glass lined reactors, total vol. 70,000 l (500 – 5,000 l) 13x stainless steel reactors, total vol. 22,000 l (1,000 – 3,000 l) 8x High performance rectification columns sufficient filtration capacity (nutsches, centrifuges) computer controlled Production Unit your partner in Fine Chemicals

  17. Toxicology, Ecology and Analytics your partner in Eco/toxicology and Analytics

  18. Analytical Techniques: NMR Spectrometry Mass Spectrometry ICP IR Spectroscopy Chromatography UV-VIS your partner in Eco/toxicology and Analytics

  19. REACH • Complete Offer of Services by VUOS-REACH • •CONSULTING • • TESTING • • REGISTRATION your partner in Eco/toxicology and Analytics

  20. Toxicology, Ecology and Analytics • •Toxicology / ecotoxicology testing • • Sampling, analysing, evaluation of production waste streams (air pollution, effluents, solid wastes hazards) • • Environmental Impact Assessment • • Development/validation of newspecialisedanalytical methods your partner in Eco/toxicology and Analytics

  21. Contacts General Manager:Dr. Karel Novák Phone:+420 46 682 2550 fax:+420 46 682 2976 e-mail:karel.novak@vuos.com Sales Manager: Miloš Jesenský,Ph.D. Phone:+420 46 682 3300 fax:+420 46 682 2976 e-mail:milos.jesensky@vuos.com R&D :Alois Koloničný, Ph.D. Phone:+420 46 682 3156 fax: +420 46 682 3900 e-mail:alois.kolonicny@vuos.com Toxicology and Analytics:Viktor Mejstřík,Ph.D. Phone:+420 46 682 3127 fax:+420 46 682 2975 e-mail:viktor.mejstrik@vuos.com Process Engineering: Luboš Víšek Phone:+420 46 682 5790 fax:+420 46 682 3900 e-mail:lubos.visek@vuos.com www.vuos.com Our team is ready for co-operation with you

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