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Late-outcomes of TB-IRIS

Late-outcomes of TB-IRIS. William Worodria , MBChB , MMed , PhD Senior EDCTP Fellow Infectious Disease Institute, Kampala, Uganda Mulago Hospital & Complex, Kampala, Uganda. Study objective.

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Late-outcomes of TB-IRIS

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  1. Late-outcomes of TB-IRIS William Worodria, MBChB, MMed, PhD Senior EDCTP Fellow Infectious Disease Institute, Kampala, Uganda Mulago Hospital & Complex, Kampala, Uganda The Rainbow of IRIS in HIV, 26th July 2012

  2. Study objective To determine if there are differences in treatment outcomes between TB-HIV co-infected patients with and without TB-IRIS: • CD4 changes with treatment • Mortality • Loss to follow up The Rainbow of IRIS in HIV, 26th July 2012

  3. Methodology Site: Mulago National TB treatment centre Design: Case-control design. Inclusion criteria: • ART naïve adult patients co-infected with TB-HIV started on HAART (CD4<250) Exclusion criteria: • No treatment supporter • Severe liver/renal abnormalities Cases: patients with TB-IRIS Controls: patients without TB-IRIS -matched by baseline CD4 count (1:2) The Rainbow of IRIS in HIV, 26th July 2012

  4. Results From December 2007 - July 2010, we enrolled 254 patients with TB-HIV starting ART We identified: • 61 cases of TB-IRIS and • 122 controls (no TB-IRIS) The Rainbow of IRIS in HIV, 26th July 2012

  5. Median CD4 counts of patients co-infected with TB-HIV on antiretroviral therapy The Rainbow of IRIS in HIV, 26th July 2012

  6. Treatment outcomes Mortality: 6 (10%) patients with TB-IRIS died vs 18 (15%) without TB-IRIS ORmortality = 0.60, 95% CI 0.21-1.70, (p= 0.34) Loss to Follow up: 5 (8.2%) patients with TB-IRIS vs 10 (8.2%) without were lost to follow up ORloss2fu = 1.00, 95% CI 0.33- 3.04, (p=1.00) The Rainbow of IRIS in HIV, 26th July 2012

  7. Conclusion TB-IRIS in this study with a small sample size had no impact on outcomes The Rainbow of IRIS in HIV, 26th July 2012

  8. Acknowledgments Prof. R Colebunders Joseph Sempa All patients M-MJAP The Rainbow of IRIS in HIV, 26th July 2012

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