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The Molecular Basis of Inheritance

The Molecular Basis of Inheritance. replication. The flow of information:. 1. Storage. 2. Replication. 3. Expression. DNA as the Genetic Material. *1868 Friedrick Miescher. *1910 Phoebus Levene. *1927 Frederick Griffith. *1952 Hershey and Chase. Review nucleotide structure:.

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The Molecular Basis of Inheritance

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  1. The Molecular Basis of Inheritance replication The flow of information: 1. Storage 2. Replication 3. Expression DNA as the Genetic Material *1868 Friedrick Miescher *1910 Phoebus Levene *1927 Frederick Griffith *1952 Hershey and Chase

  2. Review nucleotide structure:

  3. Structural analysis of DNA *Composed of nucleotides *Early 1950’s Rosalind Franklin *Linus Pauling *1953 Watson and Crick Double helix

  4. *Structural organization of the genome *chromosomes

  5. DNA Replication and Synthesis •Complementarity •”It has not escaped our notice that the specific pairing we have postulated immediately suggests a possible copying mechanism … “ •Mode of DNA Replication Semiconservative

  6. *Overview: DNA replication • *Complementarity determines which nucleotide will be added • *Chain elongation in a 5’-to-3’ direction

  7. Initiation *Strands must separate •Helicases •SSBPs •DNA gyrase *Primase *Two strands of a double helix are antiparallel •Continuous DNA synthesis = leading •Discontinuous DNA synthesis = lagging

  8. A large team of enzymes carry out DNA replication: •Helicases •SSBPs •DNA gyrase Elongation: •Association of polymerase •Sliding clamp •Primase •DNA synthesis (DNA pol) •Primer removal and replacement (DNA pol) •Ligase closes the gaps

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