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Eclampsia and Severe Pre-eclampsia

Eclampsia and Severe Pre-eclampsia. ESMOE. Importance of pre-/eclampsia. No 1 direct cause of Maternal Mortality (MM) and No 2 overall cause of MM in RSA 60% of deaths are associated with substandard care

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Eclampsia and Severe Pre-eclampsia

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  1. Eclampsia and Severe Pre-eclampsia ESMOE

  2. Importance of pre-/eclampsia No 1 direct cause of Maternal Mortality (MM) and No 2 overall cause of MM in RSA • 60% of deaths are associated with substandard care Pre-eclampsia is a disease of the endothelium and therefore potentially always multi-organ

  3. Diagnosis: Hypertension (HT) in pregnancy • Systolic BP > 140mmHg or a diastolic BP > 90 mmHg on more than 2 occasions at least 6 hours apart • Severe HT is a BP of more than 160/110 mmHg • Gestational HT and pre-eclampsia are diagnosed after 20 weeks.

  4. Diagnosis of Pre-eclampsia • Hypertension after 20 weeks with 1 or more of the following: • Proteinuria • Renal impairment • Liver impairment • Haematological impairment • Neurological impairment • Growth restriction The range of organs affected are a result of endothelial dysfunction

  5. Principles of management Stabilise mother and then deliver fetus Treat and prevent fits Treat raised blood pressure (BP) Attention to fluid balance Be aware of and prevent complications

  6. Check pulse and blood pressure Airways Breathing Disability : use AVPU system Alert V responds to voice P responds to pain Unresponsive Controling convulsions 6

  7. Fitting or unconscious Call for help Left lateral position Check pulse and blood pressure Assess and if necessary, maintain airway Oxygen and assess breathing Establish fluid balance – urinary catheter 7

  8. Magnesium Sulphate: the anticonvulsant of choice Loading dose:14g • 4g in 200mls fluid – standard giving set – administered over 20 mins • 5g with 1ml lignocaine IM in each buttock Maintenance: • 5g with 1ml lignocaine IM every 4 hours to until 24 hours after birth or 24 hours after last convulsion

  9. Magnesium caution! • Do not give the next dose of magnesium if • Absent knee jerk • Urine output less than 100 mls in last 4 hours (< 25ml/hr) • Respiratory rate less than 16 breaths per minute • If respiratory rate less than 16 breaths / minute stop magnesium and give calcium gluconate 1 g iv over 10 minutes

  10. Magnesium Sulphate • If convulsions recur give an additional 2g + 2g IV over 10-15 minutes • Give lower dose (2g) if patient is small and/ or weight is less than 70kg

  11. Oral Rx Nifedipine 10mg po Repeat every 15 minutes → 4 doses or until BP < 160/110 Contra-indications Pulse > 120 Cardiac lesion Unable to swallow Parenteral Rx Labetolol 20, 40, 80, 80 and 80mg (max 300mg) Give a bolus every 10 mins until BP < 160/110 Contra-indications Patients with asthma and ischaemic heart disease Managing HT (BP > 160/110 at risk of CVA)

  12. Fluid management Catheterise & start Intake/output chart IV Ringers Lactate (R/L) 125 ml/hr Output < 30ml/hr give 200ml R/L bolus Urine output <30ml/hr – reduce IV to 80ml/hr

  13. Fluid Mx 2 It is better to run a patient dry than drown them! Capillaries are leaky therefore control fluid input to prevent cerebral and pulmonary oedema Because of the capillary leak patients are intra-vascularly dehydrated and should not receive diuretics

  14. Big 5 CNS Resp. System CVS Liver and GIT Renal Forgotten 4 Hematological Immune system Musculosceletal Endocrine Core 1 Obstetrical EVALUATION: Mother

  15. Systemic clinical exam that include. • High care observations. • AVPU, RR, BP, pulse, sats, fluid balance chart. • Biochemical eval. • Hematocrit, platelets. • Creatinine, AST. • 24 hour protein clearance.

  16. Maternal stabilisation Is only complete when the lab results are back and this allows evaluation of the organ systems (can do bedside Hb & clotting time if lab slow/unavailable) It is not appropriate to monitor the fetus prior to this

  17. Evaluation of fetus • Evaluate fetus for viability • If viable give 12 mg betamethasone • Arrange transfer or • Consult re-termination of pregnancy • There is no place for expectant management in district hospitals!

  18. Delivery Pre-eclampsia is a disease of pregnancy and the only cure is to end the pregnancy Terminate pre-viable pregnancies Vaginal delivery at an appropriate level of care is optimal It is often necessary to individualise Mx

  19. After delivery Monitor in a “designated area” until diuresis occurs Remember (pre-)eclampsia can get worse or first fit can occur in post partum period Continue magnesium for 24 hours – no need to “tail off” Continue antihypertensives

  20. ?

  21. Recap • Recognition of Eclampsia and Severe pre- eclampsia • Resuscitation and drug management • Use of Magnesuim sulphate • Monitoring of patients on magnesium sulphate • Fluid management • Complications of (pre-) eclampsia • Delivery of a patient with eclampsia or pre- eclampsia

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