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Prognostic Value of High-Sensitivity Cardiac Troponins in Acute Coronary Syndrome

This study presents Kaplan-Meier curves illustrating cumulative rates of the combined endpoint, death/Myocardial Infarction (MI), based on cardiac troponin levels, cTnI and hs-cTnT, over a median follow-up period of 271 days. The analysis reveals significant survival probabilities associated with different thresholds of these biomarkers, indicating their diagnostic and prognostic importance in patients with acute coronary syndrome. The results show a strong correlation between elevated cTn levels and increased risk of adverse events, emphasizing the value of high-sensitivity assays in clinical practice.

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Prognostic Value of High-Sensitivity Cardiac Troponins in Acute Coronary Syndrome

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  1. Supplemental Fig. 1 Kaplan-Meier curves demonstrating rates of the combined endpoint death/MI over a median follow-up period of 271 days when elevations of either cTnI or hs-cTnT were present. 100 100 95 95 hs-cTnT<99th 90 90 cTnI<99th 85 85 80 80 hs-cTnT≥99th Survival probability (%) 75 75 cTnI≥99th 70 70 Logrank 28,99 p<0.0001 Logrank 32,50 p<0.0001 65 65 60 60 55 55 0 200 400 600 800 1000 1200 0 200 400 600 800 1000 1200 Time Time Number at risk Number at risk cTnI<99th: hs-cTnT<99th: 393 319 117 35 14 4 0 306 252 84 27 11 5 0 cTnI≥99th: hs-cTnT≥99th: 984 739 266 103 49 9 1 1071 806 299 111 52 8 1 Mueller M et al. - Diagnostic and prognostic performance of a novel high-sensitivity cardiac troponin T assay compared to a contemporary sensitive cardiac troponin I assay in patients with acute coronary syndrome, Clinical Research in Cardiology

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