1 / 9

Sharpless Asymmetric Dihydroxylation

Sharpless Asymmetric Dihydroxylation. Standard Dihydroxylation. Possible [3+2] Cycloaddition. (DHQD) 2 PHAL (found in AD-mix b) 1,4-bis(9-O- d i h ydro q uini d ine) phthalizine. Coordination of a chiral amine to the OsO 4 leads to an asymmetric complex.

mercury
Télécharger la présentation

Sharpless Asymmetric Dihydroxylation

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. SharplessAsymmetric Dihydroxylation

  2. Standard Dihydroxylation

  3. Possible [3+2] Cycloaddition

  4. (DHQD)2PHAL (found in AD-mix b)1,4-bis(9-O-dihydroquinidine)phthalizine • Coordination of a chiral amine to the OsO4 leads to an asymmetric complex.

  5. Sharpless Asymmetric Dihydroxylation

  6. Use a Pre-mix of reagent components

  7. The Ligand Accelerates the Reaction Transfers the Chiral Information M. H. Junttila, O. E. O. Hormi, J. Org. Chem., 2004, 69, 4816-4820.

More Related